Traits

Traits linked to TNFSF4

TNF superfamily member 4

The Human Phenotype Ontology links 72 traits to TNFSF4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Cataplexy	Very often (80–99%)
Difficulty sleeping	Very often (80–99%)
Excessive daytime sleepiness	Very often (80–99%)
Hallucinations	Very often (80–99%)
Transient global amnesia	Very often (80–99%)
Abnormal rapid eye movement sleep	Often (30–79%)
Anxiety	Often (30–79%)
Attention deficit	Often (30–79%)
Hypnagogic hallucination	Often (30–79%)
Hypnopompic hallucination	Often (30–79%)
NREM parasomnia	Often (30–79%)
Willis-Ekbom disease	Often (30–79%)
Depression	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)
Migraine	Sometimes (5–29%)
Pauses in breathing while sleeping	Sometimes (5–29%)
Restlessness	Sometimes (5–29%)
Sleep paralysis	Sometimes (5–29%)
Slurred speech	Sometimes (5–29%)
Chorea	Rarely (1–4%)
Psychosis	Rarely (1–4%)

Abnormality of the immune system

Trait	How often it is seen
Antinuclear antibody positivity	Very often (80–99%)
Anti-complement component C1q antibody positivity	Often (30–79%)
Anti-ribosome Po antibody positivity	Often (30–79%)
Anti-titin antibody positivity	Often (30–79%)
Antineutrophil antibody positivity	Often (30–79%)
Decreased circulating complement C3 concentration	Often (30–79%)
Decreased circulating complement C4 concentration	Often (30–79%)
Malar rash	Often (30–79%)
Anti-dsDNA antibody positivity	Sometimes (5–29%)
Anti-La/SS-B antibody positivity	Sometimes (5–29%)
Anti-nucleoporin 62 antibody positivity	Sometimes (5–29%)
Anti-phosphatidic acid antibody positivity	Sometimes (5–29%)
Anti-Ro52/TRIM21 antibody positivity	Sometimes (5–29%)
Anti-Sm antibody positivity	Sometimes (5–29%)
Anti-U1 ribonucleoprotein antibody positivity	Sometimes (5–29%)
Discoid lupus rash	Sometimes (5–29%)
Serositis	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Drooling	Often (30–79%)
Abnormal color of the oral mucosa	Sometimes (5–29%)
Abnormality of salivation	Sometimes (5–29%)
Inflammation of the lips	Sometimes (5–29%)
Mouth sore	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
High blood pressure	Often (30–79%)
Raynaud phenomenon	Often (30–79%)
Fainting spell	Sometimes (5–29%)
Swollen lymph nodes	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Female sexual dysfunction	Often (30–79%)
Lupus nephritis	Often (30–79%)
Male sexual dysfunction	Often (30–79%)
Nocturia	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Fever	Very often (80–99%)
High urine protein levels	Very often (80–99%)
Blood in urine	Often (30–79%)
High urine neutrophil count	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased blood leukocyte number	Often (30–79%)
Hemolytic anemia	Sometimes (5–29%)
Low platelet count	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Excessive sweating	Often (30–79%)
Hair loss	Often (30–79%)
Photosensitive skin	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Anorexia	Very often (80–99%)
Constipation	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Abnormal pupillary function	Often (30–79%)
Noninflammatory retina disease	Rarely (1–4%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthritis	Often (30–79%)
Polyarticular arthritis	Often (30–79%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Very often (80–99%)
Malaise	Very often (80–99%)

Growth abnormality

Trait	How often it is seen
Weight loss	Very often (80–99%)
Obesity	Sometimes (5–29%)

Abnormality of the endocrine system

Trait	How often it is seen
Early onset of puberty	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TNFSF4 and how often each is seen. Find out more at hpo.jax.org.

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