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Gene

RIPOR2

RHO family interacting cell polarization regulator 2

Summary

Cytogenetic location
6p22.3
Coordinates
Chromosome 6: 24,804,284–24,935,960 (GRCh38)
Exons
22 exons across 131.7 kb
Protein
1,047 amino acids
Also known as
KIAA0386, DIFF48, MYONAP
Previous symbols
C6orf32, FAM65B
MANE Select transcript
ENST00000643898.2NM_001286445.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hearing Loss and Deafness

      • Nonsyndromic Genetic Hearing Loss

        One of 97 genes linked to it

        Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.

        • ClinGen rates the link strong
        • 1 GenCC submitter rates it definitive or strong
        What knowing changes

        Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.

    How RIPOR2 is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Stretches short reads find hard
    Chromosome 6, with a bracket where RIPOR2 sits. RIPOR2 and 12 genes near it on chromosome 6, from 24,370,122 to 25,370,121.Chromosome 66p22.3p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q2724.4 Mb24.6 Mb24.8 Mb25 Mb25.2 MbDCDC2: 24,171,747–24,383,300, reverse strandDCDC2MRS2: 24,402,796–24,431,065, forward strandMRS2GPLD1: 24,418,076–24,495,205, reverse strandGPLD1ALDH5A1: 24,494,788–24,544,150, forward strandALDH5A1KIAA0319: 24,544,104–24,646,197, reverse strandKIAA0319TDP2: 24,649,917–24,667,052, reverse strandTDP2ACOT13: 24,666,901–24,714,084, forward strandACOT13C6orf62: 24,704,105–24,720,900, reverse strandC6orf62GMNN: 24,774,892–24,788,205, forward strandGMNNARMH2: 24,797,323–24,798,917, reverse strandARMH2: 24,797,373–24,809,798, reverse strandRIPOR2: 24,804,284–24,935,960, reverse strandRIPOR2CARMIL1: 25,279,062–25,620,537, forward strandCARMIL1Diagram of RIPOR2: 22 exons on the reverse strand of chromosome 6Exon 22: 24,804,284–24,806,473, 2,190 basesExon 21: 24,809,717–24,809,807, 91 basesExon 20: 24,818,542–24,818,625, 84 basesExon 19: 24,825,226–24,825,428, 203 basesExon 18: 24,828,137–24,828,295, 159 basesExon 17: 24,830,509–24,830,670, 162 basesExon 16: 24,832,256–24,832,391, 136 basesExon 15: 24,835,703–24,835,871, 169 basesExon 14: 24,839,091–24,839,272, 182 basesExon 13: 24,842,862–24,843,554, 693 basesExon 12: 24,848,025–24,848,154, 130 basesExon 11: 24,849,802–24,849,950, 149 basesExon 10: 24,850,597–24,850,722, 126 basesExon 9: 24,852,575–24,852,618, 44 basesExon 8: 24,860,973–24,861,036, 64 basesExon 7: 24,865,301–24,865,450, 150 basesExon 6: 24,869,094–24,869,147, 54 basesExon 5: 24,870,866–24,870,889, 24 basesExon 4: 24,872,881–24,872,959, 79 basesExon 3: 24,873,644–24,873,799, 156 basesExon 2: 24,875,691–24,875,817, 127 basesExon 1: 24,935,838–24,935,960, 123 bases22201510515′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 5.3 kb of the gene's 131.7 kb; 3,144 of those bases code for the protein.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). RIPOR2 gene: RHO family interacting cell polarization regulator 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/ripor2

    Vancouver

    Dante Labs. RIPOR2 gene: RHO family interacting cell polarization regulator 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/ripor2

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