Traits

Traits linked to SLC35C1

solute carrier family 35 member C1

The Human Phenotype Ontology links 80 traits to SLC35C1, by body system: features seen in people with one of the gene's rare conditions.

SLC35C1

Abnormality of head or neck

Trait	How often it is seen
Bulbous nose	Always
Coarse facial features	Always
Widow's peak	Always
Abnormally small head	Sometimes (5–29%)
Big lower jaw	Sometimes (5–29%)
Broad eyebrow	Sometimes (5–29%)
Deep philtrum	Sometimes (5–29%)
Depressed nasal bridge	Sometimes (5–29%)
Early tooth loss	Sometimes (5–29%)
Flat nose	Sometimes (5–29%)
Fullness of eyelids	Sometimes (5–29%)
Gum enlargement	Sometimes (5–29%)
Long eyelashes	Sometimes (5–29%)
Long upper lip	Sometimes (5–29%)
Low frontal hairline	Sometimes (5–29%)
Narrow palate	Sometimes (5–29%)
Protruding tongue	Sometimes (5–29%)
Severe gum disease	Sometimes (5–29%)
Wide nasal bridge	Sometimes (5–29%)
Gum disease	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Autism spectrum disorder	Always
Delayed speech and language development	Always
Global developmental delay	Always
Intellectual disability, severe	Always
Anxiety	Often (30–79%)
Autism	Often (30–79%)
Degeneration of cerebrum	Often (30–79%)
Difficulty sleeping	Often (30–79%)
Echoing another person's speech	Often (30–79%)
Epilepsy	Often (30–79%)
Febrile seizure (within the age range of 3 months to 6 years)	Often (30–79%)
Obsessive compulsive behavior	Often (30–79%)
Ataxia	Sometimes (5–29%)
Clumsy tandem walking	Sometimes (5–29%)
Increased reflexes	Sometimes (5–29%)
Underdeveloped frontal lobe	Sometimes (5–29%)
Decrease in size of the outer layer of the brain due to loss of brain cells	Not recorded
Intellectual disability	Not recorded

Abnormality of limbs

Trait	How often it is seen
Prominent fingertip pads	Always
Short fingers or toes	Always
Short foot	Always
Small hand	Always
Broad palm	Sometimes (5–29%)
Limb undergrowth	Sometimes (5–29%)
Lower limb hypertonia	Sometimes (5–29%)
Overlapping toe	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Abnormal level of natural antibody to blood group agents	Very often (80–99%)
Recurrent infections	Very often (80–99%)
Unusual bronchiolitis	Often (30–79%)
Chronic lymphocytic meningitis	Sometimes (5–29%)
Recurrent pneumonia	Sometimes (5–29%)
Pneumonia	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Elevated white blood count	Very often (80–99%)
Increased blood neutrophil counts	Very often (80–99%)
Low number of red blood cells or hemoglobin	Very often (80–99%)
Microcytic anemia	Often (30–79%)
Reduction of neutrophil motility	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Chronic diarrhea	Sometimes (5–29%)
Enlarged liver	Sometimes (5–29%)
Recurrent gastroenteritis	Sometimes (5–29%)
Umbilical hernia	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Recurrent middle ear infection	Always
Conductive deafness	Sometimes (5–29%)
Small earlobe	Sometimes (5–29%)
Small ears	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Generalized decreased muscle tone	Sometimes (5–29%)
Scarring	Sometimes (5–29%)
Bacterial infection of skin	Not recorded
Low muscle tone	Not recorded

Growth abnormality

Trait	How often it is seen
Short stature	Always
Faltering weight	Very often (80–99%)
Prenatal growth deficiency	Often (30–79%)
Small for gestational age	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Corneal inflammation	Sometimes (5–29%)
Esodeviation	Sometimes (5–29%)
Wide-set eyes	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Skin vesicle	Sometimes (5–29%)
Abnormality of the integument	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Frequent urinary tract infections	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Episodic fever	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SLC35C1 and how often each is seen. Find out more at hpo.jax.org.

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