{
  "url": "https://dantelabs.com/genes/ren",
  "gene": {
    "slug": "ren",
    "symbol": "REN",
    "name": "renin",
    "hgnc": "HGNC:9958",
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    "location": "1q32.1",
    "locusType": "gene with protein product",
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    "previousSymbols": [],
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    "uniprot": [
      "P00797"
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      "release": "v1.5",
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      "ensemblTranscript": "ENST00000272190.9",
      "refseqTranscript": "NM_000537.4",
      "ensemblProtein": "ENSP00000272190.8",
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    },
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      "build": "GRCh37",
      "release": "87",
      "chrom": "1",
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      "end": 204135465,
      "strand": "-"
    },
    "neighbourhood": {
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      "genes": [
        {
          "symbol": "ATP2B4",
          "ensemblId": "ENSG00000058668",
          "biotype": "protein_coding",
          "start": 203626664,
          "end": 203744081,
          "strand": "+",
          "slug": "atp2b4"
        },
        {
          "symbol": "LAX1",
          "ensemblId": "ENSG00000122188",
          "biotype": "protein_coding",
          "start": 203765169,
          "end": 203778175,
          "strand": "+",
          "slug": "lax1"
        },
        {
          "symbol": "ZC3H11A",
          "ensemblId": "ENSG00000058673",
          "biotype": "protein_coding",
          "start": 203795562,
          "end": 203854999,
          "strand": "+",
          "slug": "zc3h11a"
        },
        {
          "symbol": "ZBED6",
          "ensemblId": "ENSG00000257315",
          "biotype": "protein_coding",
          "start": 203795623,
          "end": 203854999,
          "strand": "+",
          "slug": "zbed6"
        },
        {
          "symbol": "",
          "ensemblId": "ENSG00000288644",
          "biotype": "protein_coding",
          "start": 203802094,
          "end": 203802192,
          "strand": "+"
        },
        {
          "symbol": "SNRPE",
          "ensemblId": "ENSG00000182004",
          "biotype": "protein_coding",
          "start": 203861496,
          "end": 203871152,
          "strand": "+",
          "slug": "snrpe"
        },
        {
          "symbol": "SOX13",
          "ensemblId": "ENSG00000143842",
          "biotype": "protein_coding",
          "start": 204073106,
          "end": 204127744,
          "strand": "+",
          "slug": "sox13"
        },
        {
          "symbol": "ETNK2",
          "ensemblId": "ENSG00000143845",
          "biotype": "protein_coding",
          "start": 204131062,
          "end": 204152184,
          "strand": "-",
          "slug": "etnk2"
        },
        {
          "symbol": "KISS1",
          "ensemblId": "ENSG00000170498",
          "biotype": "protein_coding",
          "start": 204190337,
          "end": 204196638,
          "strand": "-",
          "slug": "kiss1"
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        {
          "symbol": "GOLT1A",
          "ensemblId": "ENSG00000174567",
          "biotype": "protein_coding",
          "start": 204198157,
          "end": 204214121,
          "strand": "-",
          "slug": "golt1a"
        },
        {
          "symbol": "PLEKHA6",
          "ensemblId": "ENSG00000143850",
          "biotype": "protein_coding",
          "start": 204218851,
          "end": 204378391,
          "strand": "-",
          "slug": "plekha6"
        },
        {
          "symbol": "PPP1R15B",
          "ensemblId": "ENSG00000158615",
          "biotype": "protein_coding",
          "start": 204396492,
          "end": 204411887,
          "strand": "-",
          "slug": "ppp1r15b"
        },
        {
          "symbol": "PIK3C2B",
          "ensemblId": "ENSG00000133056",
          "biotype": "protein_coding",
          "start": 204421803,
          "end": 204494858,
          "strand": "-",
          "slug": "pik3c2b"
        },
        {
          "symbol": "MDM4",
          "ensemblId": "ENSG00000198625",
          "biotype": "protein_coding",
          "start": 204516369,
          "end": 204558120,
          "strand": "+",
          "slug": "mdm4"
        },
        {
          "symbol": "LRRN2",
          "ensemblId": "ENSG00000170382",
          "biotype": "protein_coding",
          "start": 204617170,
          "end": 204685745,
          "strand": "-",
          "slug": "lrrn2"
        }
      ],
      "truncated": false
    },
    "reports": [
      {
        "slug": "autosomal-dominant-tubulointerstitial-kidney-disease",
        "name": "Autosomal Dominant Tubulointerstitial Kidney Disease",
        "diseases": [
          {
            "mondoId": "MONDO:0000608",
            "name": "Familial Juvenile Hyperuricemic Nephropathy",
            "genes": 5,
            "inheritance": "autosomal-dominant",
            "description": "A dominantly inherited tubulointerstitial kidney disease, most often caused by UMOD variants (and also REN or SEC61A1), with high uric acid, early gout and gradual loss of kidney function.",
            "management": "Knowing supports kidney function monitoring, gout treatment and careful evaluation of related living kidney donors; the REN form may respond to fludrocortisone.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-dominant"
              ]
            },
            "sameAsReport": false,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/conditions/autosomal-dominant-tubulointerstitial-kidney-disease"
      },
      {
        "slug": "renal-tubular-dysgenesis",
        "name": "Renal Tubular Dysgenesis",
        "diseases": [
          {
            "mondoId": "MONDO:0017609",
            "name": "Renal Tubular Dysgenesis",
            "genes": 4,
            "inheritance": "autosomal-recessive",
            "description": "A recessive disorder of the renin-angiotensin system caused by variants in REN, AGT, ACE or AGTR1, leading to absent urine production before birth and usually fatal in the newborn period.",
            "management": "Carrier status can inform reproductive planning for couples.",
            "evidence": {
              "gencc": [
                "Ambry Genetics",
                "ClinGen",
                "Labcorp Genetics (formerly Invitae)",
                "PanelApp Australia"
              ],
              "clingen": "Definitive",
              "acmgSf": false,
              "inheritance": [
                "autosomal-recessive"
              ]
            },
            "sameAsReport": true,
            "broad": false
          }
        ],
        "url": "https://dantelabs.com/conditions/renal-tubular-dysgenesis"
      }
    ],
    "pharmacogenomics": [],
    "traits": [],
    "phenotypes": [
      {
        "slug": "microcephaly",
        "name": "Abnormally small head",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system",
          "abnormality-of-the-nervous-system"
        ],
        "url": "https://dantelabs.com/traits/microcephaly"
      },
      {
        "slug": "anuria",
        "name": "Absent urine output",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/anuria"
      },
      {
        "slug": "chronic-kidney-disease",
        "name": "Chronic kidney disease",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/chronic-kidney-disease"
      },
      {
        "slug": "focal-segmental-glomerulosclerosis",
        "name": "Focal segmental glomerulosclerosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/focal-segmental-glomerulosclerosis"
      },
      {
        "slug": "hyperuricemia",
        "name": "High blood uric acid level",
        "systems": [
          "abnormality-of-metabolism-homeostasis"
        ],
        "url": "https://dantelabs.com/traits/hyperuricemia"
      },
      {
        "slug": "proteinuria",
        "name": "High urine protein levels",
        "systems": [
          "abnormality-of-metabolism-homeostasis",
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/proteinuria"
      },
      {
        "slug": "hyperechogenic-kidneys",
        "name": "Hyperechogenic kidneys",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/hyperechogenic-kidneys"
      },
      {
        "slug": "hypotension",
        "name": "Low blood pressure",
        "systems": [
          "abnormality-of-the-cardiovascular-system"
        ],
        "url": "https://dantelabs.com/traits/hypotension"
      },
      {
        "slug": "oligohydramnios",
        "name": "Low levels of amniotic fluid",
        "systems": [
          "abnormality-of-prenatal-development-or-birth"
        ],
        "url": "https://dantelabs.com/traits/oligohydramnios"
      },
      {
        "slug": "anemia",
        "name": "Low number of red blood cells or hemoglobin",
        "systems": [
          "abnormality-of-blood-and-blood-forming-tissues"
        ],
        "url": "https://dantelabs.com/traits/anemia"
      },
      {
        "slug": "pulmonary-hypoplasia",
        "name": "Poorly developed lungs",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/pulmonary-hypoplasia"
      },
      {
        "slug": "potter-facies",
        "name": "Potter facies",
        "systems": [
          "abnormality-of-head-or-neck"
        ],
        "url": "https://dantelabs.com/traits/potter-facies"
      },
      {
        "slug": "renal-tubular-atrophy",
        "name": "Renal tubular atrophy",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/renal-tubular-atrophy"
      },
      {
        "slug": "renotubular-dysgenesis",
        "name": "Renotubular dysgenesis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/renotubular-dysgenesis"
      },
      {
        "slug": "respiratory-insufficiency",
        "name": "Respiratory function loss",
        "systems": [
          "abnormality-of-the-respiratory-system"
        ],
        "url": "https://dantelabs.com/traits/respiratory-insufficiency"
      },
      {
        "slug": "renal-hypoplasia",
        "name": "Small kidneys",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/renal-hypoplasia"
      },
      {
        "slug": "tubulointerstitial-fibrosis",
        "name": "Tubulointerstitial fibrosis",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/tubulointerstitial-fibrosis"
      },
      {
        "slug": "abnormality-of-the-urinary-system",
        "name": "Urinary tract abnormalities",
        "systems": [
          "abnormality-of-the-genitourinary-system"
        ],
        "url": "https://dantelabs.com/traits/abnormality-of-the-urinary-system"
      },
      {
        "slug": "widely-patent-fontanelles-and-sutures",
        "name": "Widely patent fontanelles and sutures",
        "systems": [
          "abnormality-of-head-or-neck",
          "abnormality-of-the-musculoskeletal-system"
        ],
        "url": "https://dantelabs.com/traits/widely-patent-fontanelles-and-sutures"
      }
    ],
    "related": [
      {
        "slug": "ace",
        "symbol": "ACE",
        "name": "angiotensin I converting enzyme",
        "shared": 1,
        "url": "https://dantelabs.com/genes/ace"
      },
      {
        "slug": "agt",
        "symbol": "AGT",
        "name": "angiotensinogen",
        "shared": 1,
        "url": "https://dantelabs.com/genes/agt"
      },
      {
        "slug": "agtr1",
        "symbol": "AGTR1",
        "name": "angiotensin II receptor type 1",
        "shared": 1,
        "url": "https://dantelabs.com/genes/agtr1"
      },
      {
        "slug": "hnf1b",
        "symbol": "HNF1B",
        "name": "HNF1 homeobox B",
        "shared": 1,
        "url": "https://dantelabs.com/genes/hnf1b"
      },
      {
        "slug": "muc1",
        "symbol": "MUC1",
        "name": "mucin 1, cell surface associated",
        "shared": 1,
        "url": "https://dantelabs.com/genes/muc1"
      },
      {
        "slug": "sec61a1",
        "symbol": "SEC61A1",
        "name": "SEC61 translocon subunit alpha 1",
        "shared": 1,
        "url": "https://dantelabs.com/genes/sec61a1"
      },
      {
        "slug": "umod",
        "symbol": "UMOD",
        "name": "uromodulin",
        "shared": 1,
        "url": "https://dantelabs.com/genes/umod"
      }
    ],
    "sources": {
      "bundleId": "2026.10.17-8666dff2",
      "panel": "2026-10-17",
      "acmgSf": "SF v3.2"
    },
    "locusKind": "proteinCoding"
  },
  "variants": {
    "total": 0,
    "url": null,
    "items": []
  }
}