Traits

Traits linked to NRAP

nebulin related anchoring protein

The Human Phenotype Ontology links 40 traits to NRAP, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the cardiovascular system

Trait	How often it is seen
Aborted sudden cardiac death	Always
Cardiac failure	Always
Decreased cardiac output	Always
Elevated left ventricular end-diastolic diameter	Always
Enlarged heart	Always
Heart stops beating	Always
High blood pressure	Always
Increased left ventricular end-diastolic volume	Always
Inflammation of heart muscle	Always
Left atrial enlargement	Always
Left bundle branch block	Always
Left ventricular dilatation	Always
Left ventricular noncompaction	Always
Low-output congestive heart failure	Always
Mitral regurgitation	Always
Myocardial late gadolinium enhancement	Always
Prolonged QTc interval	Always
Right ventricular dilatation	Always
Sinus tachycardia	Always
Stretched and thinned heart muscle	Always
Systolic heart murmur	Always
Tricuspid regurgitation	Always
Ventricular tachycardia	Always
Left ventricular systolic dysfunction	Very often (80–99%)
Abnormal heart rate	Often (30–79%)
Moderately reduced left ventricular ejection fraction	Often (30–79%)
Severely reduced left ventricular ejection fraction	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Always
EMG abnormality	Sometimes (5–29%)
Loss of fat tissue in localized area	Sometimes (5–29%)
Muscle tissue disease	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Orthopnea	Always
Respiratory tract infection	Always
Exertional breathlessness	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Elevated circulating NT-proBNP concentration	Always
Fluid retention	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Thromboembolic stroke	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Sensorineural hearing impairment	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Motor delay	Always

Constitutional symptom

Trait	How often it is seen
Fatigue	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to NRAP and how often each is seen. Find out more at hpo.jax.org.

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