Traits

Traits linked to MCFD2

multiple coagulation factor deficiency 2, ER cargo receptor complex subunit

The Human Phenotype Ontology links 19 traits to MCFD2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Prolonged partial thromboplastin time	Very often (80–99%)
Prolonged prothrombin time	Very often (80–99%)
Reduced coagulation factor V activity	Very often (80–99%)
Reduced factor VIII activity	Very often (80–99%)
Bleeding gums	Often (30–79%)
Bleeding with minor or no trauma	Often (30–79%)
Bloody nose	Often (30–79%)
Bruising susceptibility	Often (30–79%)
Prolonged bleeding after dental extraction	Often (30–79%)
Prolonged bleeding following circumcision	Often (30–79%)
Abnormally heavy bleeding during menstruation	Sometimes (5–29%)
Bleeding within a joint	Sometimes (5–29%)
Bleeding within the skull	Sometimes (5–29%)
Gastrointestinal bleeding	Sometimes (5–29%)
Prolonged bleeding after surgery	Sometimes (5–29%)
Excessive bleeding after minor trauma	Not recorded

Laboratory abnormality

Trait	How often it is seen
Blood in urine	Sometimes (5–29%)
Elevated lipids in blood	Rarely (1–4%)
High blood uric acid level	Rarely (1–4%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MCFD2 and how often each is seen. Find out more at hpo.jax.org.

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