Trait

Reduced coagulation factor V activity

Decreased activity of coagulation factor V.

HPO HP:0003225

Also called: Reduced factor V activity
Body system: Abnormality of blood and blood-forming tissues

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4 genes linked to Reduced coagulation factor V activity

Changes in these genes cause rare conditions in which Reduced coagulation factor V activity is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
LMAN1lectin, mannose binding 1	Very often (80–99%)	In 2 conditions
MCFD2multiple coagulation factor deficiency 2, ER cargo receptor complex subunit	Very often (80–99%)	In 2 conditions
SLC37A4solute carrier family 37 member 4	Very often (80–99%)	In 1 condition
F5coagulation factor V	Not recorded	In 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal coagulation factor V activity

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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