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Gene

CCT2

chaperonin containing TCP1 subunit 2

Summary

Cytogenetic location
12q15
Coordinates
Chromosome 12: 69,585,459–69,601,570 (GRCh38)
Exons
16 exons across 16.1 kb
Protein
535 amino acids
Inheritance
Autosomal recessive
Also known as
Cctb
MANE Select transcript
ENST00000299300.11NM_006431.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Leber Congenital Amaurosis & RPE65-Related Retinopathy

    • Leber Congenital AmaurosisAutosomal recessive

      A group of inherited retinal dystrophies, caused by changes in genes such as CEP290, GUCY2D, CRB1, RPE65 and AIPL1, that cause severe vision loss, nystagmus and poor pupil responses in infancy.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Confirming the gene can determine eligibility for gene-specific treatments and clinical trials, and informs family counselling.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How CCT2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 12, with a bracket where CCT2 sits. CCT2 and 9 genes near it on chromosome 12, from 69,093,515 to 70,093,514.Chromosome 1212q15p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3369.2 Mb69.4 Mb69.6 Mb69.8 Mb70 MbCPSF6: 69,239,543–69,279,829, forward strandCPSF6LYZ: 69,348,381–69,354,237, forward strandLYZYEATS4: 69,359,669–69,398,005, forward strandYEATS4FRS2: 69,470,349–69,579,793, forward strandFRS2CCT2: 69,585,459–69,601,570, forward strandCCT2LRRC10: 69,608,564–69,610,907, reverse strandLRRC10BEST3: 69,643,360–69,699,476, reverse strandBEST3RAB3IP: 69,738,785–69,823,204, forward strandRAB3IP: 69,801,669–69,855,363, forward strandMYRFL: 69,825,222–69,959,097, forward strandMYRFLDiagram of CCT2: 16 exons on the forward strand of chromosome 12Exon 1: 69,585,459–69,585,524, 66 basesExon 2: 69,586,270–69,586,344, 75 basesExon 3: 69,586,753–69,586,818, 66 basesExon 4: 69,587,505–69,587,616, 112 basesExon 5: 69,587,930–69,588,006, 77 basesExon 6: 69,588,150–69,588,262, 113 basesExon 7: 69,589,485–69,589,687, 203 basesExon 8: 69,592,059–69,592,159, 101 basesExon 9: 69,592,976–69,593,103, 128 basesExon 10: 69,593,510–69,593,613, 104 basesExon 11: 69,597,156–69,597,275, 120 basesExon 12: 69,597,638–69,597,766, 129 basesExon 13: 69,597,968–69,598,071, 104 basesExon 14: 69,598,322–69,598,421, 100 basesExon 15: 69,599,863–69,600,004, 142 basesExon 16: 69,601,295–69,601,570, 276 bases12468101214165′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 16.1 kb; 1,608 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CCT2 gene: chaperonin containing TCP1 subunit 2. Retrieved 17 October 2026, from https://dantelabs.com/genes/cct2

Vancouver

Dante Labs. CCT2 gene: chaperonin containing TCP1 subunit 2 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/cct2

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