Traits

Traits linked to KRT6A

keratin 6A

The Human Phenotype Ontology links 34 traits to KRT6A, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the integument

Trait	How often it is seen
Overgrowth and curving of toenails	Always
Poor nail formation	Always
Abnormal fingernail development	Often (30–79%)
Epidermoid cyst	Often (30–79%)
Follicular hyperkeratosis	Often (30–79%)
Linear arrays of macular hyperkeratoses in flexural areas	Often (30–79%)
Overgrowth and curving of fingernail	Often (30–79%)
Skin cyst	Often (30–79%)
Steatocystoma multiplex	Often (30–79%)
Eruptive vellus hair cyst	Sometimes (5–29%)
Paronychia	Sometimes (5–29%)
Hair loss	Rarely (1–4%)
Excessive sweating	Not recorded
Thick nail	Not recorded

Abnormality of head or neck

Trait	How often it is seen
Oral white patch	Always
Born with teeth	Sometimes (5–29%)
Early eruption of teeth	Sometimes (5–29%)
Inflammation of corners of the mouth	Rarely (1–4%)
Chapped lip	Not recorded
Grooved tongue	Not recorded
Inflamed gums	Not recorded

Abnormality of limbs

Trait	How often it is seen
Thickening of the outer layer of the skin of the palms and soles	Always
Palmoplantar blistering	Very often (80–99%)
Thickening of palms and soles	Very often (80–99%)
Excessive sweating of palms and soles	Often (30–79%)
Palmar hyperkeratosis	Often (30–79%)
Plantar hyperkeratosis	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Hyperplastic callus formation	Very often (80–99%)
Lower limb pain	Very often (80–99%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Ear pain	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Breathing difficulties	Rarely (1–4%)

Abnormality of the voice

Trait	How often it is seen
Hoarse voice	Rarely (1–4%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KRT6A and how often each is seen. Find out more at hpo.jax.org.

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