Traits

Traits linked to IHH

Indian hedgehog signaling molecule

The Human Phenotype Ontology links 72 traits to IHH, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of limbs

Trait	How often it is seen
Delayed maturation of wrist bone	Always
Limb undergrowth	Always
Short fingers or toes	Always
Short middle bone of finger	Always
Short neck of thighbone	Always
Single interphalangeal crease of fifth finger	Always
Abnormal neck of thigh bone	Very often (80–99%)
Coxa vara	Very often (80–99%)
Short big toe	Very often (80–99%)
Short foot	Very often (80–99%)
Short palm	Very often (80–99%)
Short thumb	Very often (80–99%)
Smaller or shorter than typical limbs	Very often (80–99%)
Bowing of outer large bone of the forearm	Often (30–79%)
Cone-shaped end part of long bone	Often (30–79%)
Outward bow-leggedness	Often (30–79%)
Club feet	Sometimes (5–29%)
Curvature of little finger	Sometimes (5–29%)
Enlarged humeral head	Sometimes (5–29%)
Fused outermost bones of hand	Sometimes (5–29%)
Underdeveloped inner large forearm bone	Sometimes (5–29%)
Wide long bones of hand	Sometimes (5–29%)
Abnormality of femoral head development	Not recorded
Absent distal interphalangeal creases	Not recorded
Absent/small middle bones of toe	Not recorded
Absent/small middle finger bone of the hand	Not recorded
Broad end part of long bone of hand	Not recorded
Broad palm	Not recorded
Cone-shaped end part of finger bones	Not recorded
Cone-shaped end part of innermost thighbone	Not recorded
Cone-shaped end part of the 1st long bone of hand	Not recorded
Enlargement of the outermost thighbone end part	Not recorded
Flattened head of long bone of foot	Not recorded
Inward turned middle finger	Not recorded
Overgrowth of calf bone	Not recorded
Proportionate shortening of all digits	Not recorded
Radial deviation of the 2nd finger	Not recorded
Radial deviation of the 4th finger	Not recorded
Short humerus	Not recorded
Short innermost big toe bone	Not recorded
Short outermost finger bone	Not recorded
Short proximal phalanx of finger	Not recorded
Short proximal phalanx of thumb	Not recorded
Short shinbone	Not recorded
Short thighbone	Not recorded
Shortened long bone of hand	Not recorded
Slender long bones of hand	Not recorded
Small finger	Not recorded
Thin innermost bone with broad end part of the hand bone	Not recorded
Underdeveloped outer large forearm bone	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Abnormal skeletal development	Very often (80–99%)
Cone-shaped end part of bone	Very often (80–99%)
Delayed bone maturation	Very often (80–99%)
Cupped ribs	Often (30–79%)
Excessive inward curvature of lower spine	Often (30–79%)
Flared iliac wing	Often (30–79%)
Narrow chest	Often (30–79%)
Ovoid vertebral bodies	Often (30–79%)
Prominent swayback	Often (30–79%)
Funnel chest	Sometimes (5–29%)
Pigeon chest	Sometimes (5–29%)
Scoliosis	Sometimes (5–29%)
Shorter than typical length between neck and abdomen	Sometimes (5–29%)
Hypoplastic iliac wing	Not recorded
Short ribs	Not recorded

Abnormality of the integument

Trait	How often it is seen
Broad nail	Always
Short nail	Always
Small nail	Often (30–79%)

Abnormality of head or neck

Trait	How often it is seen
Big calvaria	Sometimes (5–29%)
Relatively large head	Not recorded

Growth abnormality

Trait	How often it is seen
Short stature	Always
Disproportionate short-limb short stature	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to IHH and how often each is seen. Find out more at hpo.jax.org.

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