Trait
Cleft nasal bridge
Clinical name: Bifid nose
Visually assessable vertical indentation, cleft, or depression of the nasal bridge, ridge and tip.
Summary
- Also called
- Cleft nose, Indentation or clefting of the nose, Indented bridge of nose, Bifid nasal bridge
- Body system
- Abnormality of head or neck
Reference genomeGRCh38hg38
Positions on gene and variant pages follow this choice, in this browser.
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Get my Genome Test12 genes linked to Cleft nasal bridge
Changes in these genes cause rare conditions in which Cleft nasal bridge is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| FREM1FRAS1 related extracellular matrix 1 | Always | In 2 conditions |
| ALX4ALX homeobox 4 | Very often (80–99%) | In 1 condition |
| ZSWIM6zinc finger SWIM-type containing 6 | Very often (80–99%) | In 2 conditions |
| ALX1ALX homeobox 1 | Often (30–79%) | In 1 condition |
| NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor | Often (30–79%) | In 1 condition |
| NUAK2NUAK family kinase 2 | Often (30–79%) | In 1 condition |
| NF1neurofibromin 1 | Sometimes (5–29%) | In 1 condition |
| PTCH1patched 1 | Sometimes (5–29%) | In 1 condition |
| TBX4T-box transcription factor 4 | Sometimes (5–29%) | In 1 condition |
| TFE3transcription factor binding to IGHM enhancer 3 | Sometimes (5–29%) | In 1 condition |
| ALX3ALX homeobox 3 | Not recorded | In 1 condition |
| HYLS1HYLS1 centriolar and ciliogenesis associated | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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