Traits

Traits linked to FBP1

fructose-bisphosphatase 1

The Human Phenotype Ontology links 39 traits to FBP1, by body system: features seen in people with one of the gene's rare conditions.

Laboratory abnormality

Trait	How often it is seen
Low blood sugar	Always
Metabolic acidosis	Always
Reduced tissue fructose-1,6-bisphosphatase activity	Always
Abnormal circulating enzyme concentration or activity	Very often (80–99%)
Increased lactate in body	Very often (80–99%)
High blood uric acid level	Often (30–79%)
Intermittent lactic acidemia	Often (30–79%)
Low blood sugar when fasting	Often (30–79%)
Fatty infiltration of liver	Sometimes (5–29%)
High levels of ketone bodies	Sometimes (5–29%)
High liver enzymes	Sometimes (5–29%)
Increased urinary glycerol	Sometimes (5–29%)
Low blood sugar in newborn	Sometimes (5–29%)
Neonatal hyperbilirubinemia	Sometimes (5–29%)
Increased blood alanine	Rarely (1–4%)
Fever	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Coma	Sometimes (5–29%)
Disturbances of consciousness	Sometimes (5–29%)
Drowsiness	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)
Excessive daytime sleepiness	Sometimes (5–29%)
Intellectual disability	Sometimes (5–29%)
Irritability	Sometimes (5–29%)
Ventriculomegaly	Sometimes (5–29%)
Lethargy	Not recorded

Abnormality of the respiratory system

Trait	How often it is seen
Apneic episodes in infancy	Sometimes (5–29%)
Breathing difficulties	Sometimes (5–29%)
Breathing difficulty	Sometimes (5–29%)
Episodic tachypnea	Sometimes (5–29%)
Intermittent overbreathing	Sometimes (5–29%)
Apnea	Not recorded
Rapid breathing	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Diarrhea	Often (30–79%)
Vomiting	Often (30–79%)
Enlarged liver	Sometimes (5–29%)
Reye syndrome-like episodes	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Elevated heart rate	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Paleness	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to FBP1 and how often each is seen. Find out more at hpo.jax.org.

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