Traits

Traits linked to DCX

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The Human Phenotype Ontology links 42 traits to DCX, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Behavioral abnormality	Very often (80–99%)
Cognitive impairment	Very often (80–99%)
Epilepsy	Very often (80–99%)
Language impairment	Very often (80–99%)
Agyria	Often (30–79%)
Akinetic mutism	Often (30–79%)
Cerebral palsy	Often (30–79%)
Fewer and broader ridges in brain	Often (30–79%)
Generalized-onset seizure	Often (30–79%)
Infantile spasms	Often (30–79%)
Poor gross motor coordination	Often (30–79%)
Seizure affecting one half of brain	Often (30–79%)
Abnormal caudate nucleus morphology	Sometimes (5–29%)
Agitation	Sometimes (5–29%)
Autism spectrum disorder	Sometimes (5–29%)
Cerebral white matter atrophy	Sometimes (5–29%)
Delayed myelination	Sometimes (5–29%)
Epileptic encephalopathy	Sometimes (5–29%)
Hypsarrhythmia	Sometimes (5–29%)
Irritability	Sometimes (5–29%)
Lateral ventricle dilatation	Sometimes (5–29%)
Underdevelopment of part of brain called corpus callosum	Sometimes (5–29%)
Agenesis of corpus callosum	Not recorded
Ataxia	Not recorded
Difficulty articulating speech	Not recorded
Fewer or absent grooves in brain	Not recorded
Gray matter heterotopia	Not recorded
Intellectual disability	Not recorded
Motor delay	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Abnormal muscle tone	Often (30–79%)
Flexed joint that cannot be straightened	Often (30–79%)
Scoliosis	Sometimes (5–29%)
Involuntary muscle stiffness, contraction, or spasm	Not recorded
Low muscle tone in trunk	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties in infancy	Sometimes (5–29%)
Poor swallowing	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Development of small head that was not present at birth	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Dilation of Virchow-Robin spaces	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Involuntary, rapid, rhythmic eye movements	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Short penis	Not recorded

Abnormality of the respiratory system

Trait	How often it is seen
Aspiration	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Growth delay as children	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to DCX and how often each is seen. Find out more at hpo.jax.org.

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