Traits

Traits linked to ATL3

atlastin GTPase 3

The Human Phenotype Ontology links 36 traits to ATL3, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Sensory axonal neuropathy	Always
Abnormality of balance	Very often (80–99%)
Abnormality of the autonomic nervous system	Very often (80–99%)
Decreased amplitude of sensory action potentials	Very often (80–99%)
Decreased sensation in extremities	Very often (80–99%)
Impaired pain sensation	Very often (80–99%)
Numbness	Very often (80–99%)
Decreased touch sensation in extremities	Often (30–79%)
High stepping	Often (30–79%)
Impaired temperature sensation	Often (30–79%)
Pain insensitivity	Often (30–79%)
Trophic changes related to pain	Often (30–79%)
Inability to walk	Sometimes (5–29%)
Motor axonal neuropathy	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Muscle weakness	Very often (80–99%)
Limb pain	Often (30–79%)
Neuropathic arthropathy	Often (30–79%)
Weakness of outermost muscles	Often (30–79%)
Distal muscle wasting	Sometimes (5–29%)
EMG: slow motor conduction	Sometimes (5–29%)
Spontaneous fracture	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Bunion	Very often (80–99%)
Foot drop	Often (30–79%)
Metatarsal fracture	Often (30–79%)
Breakdown of small bones of fingers	Not recorded
Hyporeflexia of lower limbs	Not recorded

Abnormality of the integument

Trait	How often it is seen
Hyperkeratosis	Often (30–79%)
Lack of sweating or excessive sweating	Often (30–79%)
Open skin sore	Often (30–79%)
Penetrating foot ulcers	Often (30–79%)
Poor wound healing	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Acid reflux	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Hearing impairment	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Bone infection	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Cough	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Impaired ability to dress oneself	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ATL3 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test