Traits

Traits linked to ARPC5

actin related protein 2/3 complex subunit 5

The Human Phenotype Ontology links 32 traits to ARPC5, by body system: features seen in people with one of the gene's rare conditions.

ARPC5

Abnormality of the immune system

Trait	How often it is seen
Decreased immune function	Always
Recurrent bacterial infections	Always
Recurrent respiratory infections	Always
Eczema	Often (30–79%)
Muscle inflammation	Often (30–79%)
Recurrent fungal infections	Often (30–79%)
Recurrent viral infections	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Elevated white blood count	Always
High blood monocyte number	Always
Increased blood neutrophil counts	Always
Rectal bleeding	Always
Autoimmune hemolytic anemia	Often (30–79%)
Autoimmune thrombocytopenia	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Always
Celiac disease	Often (30–79%)
Liver inflammation	Often (30–79%)
Paralytic ileus	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Pulmonary pneumatocele	Always
Coughing up blood	Often (30–79%)
Intraalveolar phospholipid accumulation	Often (30–79%)

Abnormal cellular phenotype

Trait	How often it is seen
Increased circulating IgA concentration	Always
Increased circulating IgE concentration	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Scoliosis	Always
Involuntary muscle stiffness, contraction, or spasm	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Prenatal growth deficiency	Often (30–79%)
Short stature	Often (30–79%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Neonatal omphalitis	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Always

Abnormality of the genitourinary system

Trait	How often it is seen
Minimal change glomerulonephritis	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Poor wound healing	Always

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Elevated circulating C-reactive protein concentration	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to ARPC5 and how often each is seen. Find out more at hpo.jax.org.

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