Traits

Traits linked to AMN

amnion associated transmembrane protein

The Human Phenotype Ontology links 36 traits to AMN, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Hypersegmentation of neutrophil nuclei	Very often (80–99%)
Macrocytic anemia	Very often (80–99%)
Megaloblastic anemia	Very often (80–99%)
Abnormal hemoglobin concentration	Often (30–79%)
Anisopoikilocytosis	Often (30–79%)
Increased immature red blood cells	Often (30–79%)
Low blood neutrophil count	Often (30–79%)
Low number of red blood cells or hemoglobin	Often (30–79%)
Oval macrocytosis	Often (30–79%)
Bleeding tendency	Sometimes (5–29%)
Low blood cell count	Sometimes (5–29%)
Low platelet count	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Abnormal circulating 5-methyltetrahydrofolate concentration	Always
Malabsorption of Vitamin B12	Always
Vitamin B12 deficiency	Always
High urine protein levels	Very often (80–99%)
High urine albumin levels	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Constipation	Sometimes (5–29%)
Diarrhea	Sometimes (5–29%)
Poor appetite	Sometimes (5–29%)
Vomiting	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Abnormality of the nervous system	Sometimes (5–29%)
Delayed ability to walk	Sometimes (5–29%)
Delayed speech and language development	Sometimes (5–29%)
Loss of developmental milestones	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Faltering weight	Sometimes (5–29%)
Growth delay	Sometimes (5–29%)
Weight loss	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Inflammation of corners of the mouth	Sometimes (5–29%)
Inflammation of the tongue	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Sometimes (5–29%)
Rounded lower back	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Elevated heart rate	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Frequent urinary tract infections	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Decreased immune function	Rarely (1–4%)

Abnormality of the integument

Trait	How often it is seen
Paleness	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to AMN and how often each is seen. Find out more at hpo.jax.org.

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