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Gene

ADAMTS9

ADAM metallopeptidase with thrombospondin type 1 motif 9

Summary

Cytogenetic location
3p14.1
Coordinates
Chromosome 3: 64,515,654–64,688,000 (GRCh38)
Exons
40 exons across 172.3 kb
Protein
1,935 amino acids
Inheritance
Autosomal recessive
Also known as
KIAA1312
MANE Select transcript
ENST00000498707.5NM_182920.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Nephronophthisis and Senior-Løken Syndrome

    • NephronophthisisAutosomal recessive

      A recessively inherited kidney disease, caused by variants in NPHP1 and other cilia genes, in which progressive tubulointerstitial scarring leads to kidney failure, typically in the first three decades of life.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing allows regular kidney function monitoring, timely planning for dialysis or transplantation, and carrier testing for relatives.

Inheritance

Autosomal recessive
It takes a changed copy from each parent. With one, you are a carrier and usually unaffected; when both parents are carriers, each child has a one-in-four chance of inheriting two.

How ADAMTS9 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 3, with a bracket where ADAMTS9 sits. ADAMTS9 and 1 gene near it on chromosome 3, from 64,101,827 to 65,101,826.Chromosome 33p14.1p26.3p26.2p26.1p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p14.3p14.2p14.1p13p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12.1q12.2q12.3q13.11q13.12q13.13q13.2q13.31q13.32q13.33q21.1q21.2q21.3q22.1q22.2q22.3q23q24q25.1q25.2q25.31q25.32q25.33q26.1q26.2q26.31q26.32q26.33q27.1q27.2q27.3q28q2964.2 Mb64.4 Mb64.6 Mb64.8 Mb65 MbPRICKLE2: 64,092,236–64,445,476, reverse strandPRICKLE2ADAMTS9: 64,515,654–64,688,000, reverse strandADAMTS9Diagram of ADAMTS9: 40 exons on the reverse strand of chromosome 3Exon 40: 64,515,654–64,517,121, 1,468 basesExon 39: 64,522,166–64,522,260, 95 basesExon 38: 64,533,166–64,533,270, 105 basesExon 37: 64,539,203–64,539,294, 92 basesExon 36: 64,541,095–64,541,228, 134 basesExon 35: 64,541,320–64,541,414, 95 basesExon 34: 64,541,526–64,541,620, 95 basesExon 33: 64,541,838–64,541,970, 133 basesExon 32: 64,546,758–64,546,952, 195 basesExon 31: 64,550,892–64,551,062, 171 basesExon 30: 64,561,578–64,561,751, 174 basesExon 29: 64,568,368–64,568,535, 168 basesExon 28: 64,594,258–64,594,434, 177 basesExon 27: 64,596,830–64,596,991, 162 basesExon 26: 64,601,944–64,602,213, 270 basesExon 25: 64,603,922–64,604,089, 168 basesExon 24: 64,604,227–64,604,331, 105 basesExon 23: 64,606,960–64,607,079, 120 basesExon 22: 64,613,345–64,613,509, 165 basesExon 21: 64,615,321–64,615,485, 165 basesExon 20: 64,615,960–64,616,170, 211 basesExon 19: 64,621,114–64,621,240, 127 basesExon 18: 64,622,198–64,622,327, 130 basesExon 17: 64,622,420–64,622,586, 167 basesExon 16: 64,631,455–64,631,550, 96 basesExon 15: 64,631,808–64,631,925, 118 basesExon 14: 64,633,472–64,633,608, 137 basesExon 13: 64,633,698–64,633,879, 182 basesExon 12: 64,641,848–64,641,993, 146 basesExon 11: 64,647,940–64,648,044, 105 basesExon 10: 64,649,637–64,649,778, 142 basesExon 9: 64,651,017–64,651,163, 147 basesExon 8: 64,654,353–64,654,458, 106 basesExon 7: 64,654,572–64,654,612, 41 basesExon 6: 64,655,576–64,655,691, 116 basesExon 5: 64,655,792–64,655,875, 84 basesExon 4: 64,658,502–64,658,791, 290 basesExon 3: 64,681,201–64,681,363, 163 basesExon 2: 64,686,568–64,686,968, 401 basesExon 1: 64,687,543–64,688,000, 458 bases40353025201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 7.6 kb of the gene's 172.3 kb; 5,808 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ADAMTS9 gene: ADAM metallopeptidase with thrombospondin type 1 motif 9. Retrieved 16 October 2026, from https://dantelabs.com/genes/adamts9

Vancouver

Dante Labs. ADAMTS9 gene: ADAM metallopeptidase with thrombospondin type 1 motif 9 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/adamts9

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