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Trait

Spermatogenesis maturation arrest

Maturation arrest (MA) is defined as germ cells that fail to complete maturation. Uniform MA is characterized by spermatogenic arrest at the same stage of spermatogenesis throughout the seminiferous tubules. MA is subcategorized into early MA, in which only spermatogonia or spermatocytes are found, and late MA, in which spermatids are detected without spermatozoa.

HPO HP:0031038

Summary

Also called
Meiotic maturation arrest of spermatogenesis
Body system
Abnormality of the genitourinary system

2 condition reports read genes linked to this trait

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11 genes linked to Spermatogenesis maturation arrest

Changes in these genes cause rare conditions in which Spermatogenesis maturation arrest is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

GeneHow often it is seenConditions
MOV10L1Mov10 like RNA helicase 1AlwaysIn 1 condition
MSH5mutS homolog 5AlwaysIn 1 condition
PNLDC1PARN like ribonuclease domain containing exonuclease 1AlwaysIn 1 condition
RBBP7RB binding protein 7, chromatin remodeling factorAlwaysIn 1 condition
SYCE1synaptonemal complex central element protein 1AlwaysIn 1 condition
TDRD9tudor domain containing 9AlwaysIn 1 condition
TERB1telomere repeat binding bouquet formation protein 1AlwaysIn 1 condition
TERB2telomere repeat binding bouquet formation protein 2AlwaysIn 1 condition
TEX11testis expressed 11AlwaysIn 1 condition
XRCC2X-ray repair cross complementing 2AlwaysIn 1 condition
M1APmeiosis 1 associated proteinNot recordedIn 1 condition

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Narrower traits

Broader traits

Abnormal sperm development

Where this comes from

  • The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
  • Data release 2026.10.19-9814e911.

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