Traits

Traits linked to UBB

ubiquitin B

The Human Phenotype Ontology links 23 traits to UBB, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Bifid uvula	Always
Abnormality of the oral cavity	Often (30–79%)
Cleft soft palate	Often (30–79%)
Submucous cleft palate	Often (30–79%)
Velopharyngeal incompetence	Often (30–79%)
Cleft lip	Sometimes (5–29%)
Decreased size of maxilla	Sometimes (5–29%)
Short face	Sometimes (5–29%)
Submucous cleft soft palate	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Breathy speech	Often (30–79%)
Language impairment	Often (30–79%)
Obstructive sleep apnea	Often (30–79%)
Receptive language delay	Often (30–79%)
Speech articulation difficulties	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties in infancy	Often (30–79%)
Nasal regurgitation	Often (30–79%)
Oral-pharyngeal dysphagia	Often (30–79%)
Poor suck	Often (30–79%)

Abnormality of the ear

Trait	How often it is seen
Conductive deafness	Sometimes (5–29%)
Hearing impairment	Sometimes (5–29%)
Recurrent middle ear infection	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Aspiration pneumonia	Sometimes (5–29%)

Abnormality of the voice

Trait	How often it is seen
Nasal speech	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to UBB and how often each is seen. Find out more at hpo.jax.org.

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