Traits

Traits linked to TTI2

TELO2 interacting protein 2

The Human Phenotype Ontology links 33 traits to TTI2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Aggressive behavior	Always
Delayed ability to walk	Always
Delayed speech and language development	Always
Intellectual disability, severe	Always
IQ between 34 and 49	Always
More active than typical	Always
Repetitive movements	Always
Global developmental delay	Very often (80–99%)
Behavioral abnormality	Often (30–79%)
Difficulty sleeping	Often (30–79%)
Abnormal cerebral white matter morphology	Sometimes (5–29%)
Irritability	Sometimes (5–29%)
Underdevelopment of part of brain called corpus callosum	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always
Abnormal facial shape	Very often (80–99%)
Bad bite	Often (30–79%)
Abnormal dentition	Sometimes (5–29%)
Decreased volume of lip	Sometimes (5–29%)
Monobrow	Sometimes (5–29%)
Prominent nose	Sometimes (5–29%)
Sloping forehead	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Kyphoscoliosis	Always
Scoliosis	Often (30–79%)
Myotonia	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Bunion	Often (30–79%)
Webbed 2nd and 3rd toes	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Large ears	Sometimes (5–29%)
Anteverted ears	Not recorded

Abnormality of the eye

Trait	How often it is seen
Cross-eyed	Sometimes (5–29%)
Deeply set eye	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased blood lymphocyte number	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Early menopause	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Short stature	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TTI2 and how often each is seen. Find out more at hpo.jax.org.

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