Traits

Traits linked to TRIM37

tripartite motif containing 37

The Human Phenotype Ontology links 44 traits to TRIM37, by body system: features seen in people with one of the gene's rare conditions.

TRIM37

Abnormality of head or neck

Trait	How often it is seen
Big calvaria	Very often (80–99%)
Depressed nasal bridge	Very often (80–99%)
Frontal bossing	Very often (80–99%)
J-shaped sella turcica	Very often (80–99%)
Triangular face	Very often (80–99%)
Wide nose	Very often (80–99%)
Absent frontal sinuses	Often (30–79%)
Bad bite	Often (30–79%)
Wide nasal bridge	Often (30–79%)
Thin dental enamel	Rarely (1–4%)
Abnormally small tongue	Not recorded
Dental crowding	Not recorded
Failure of development of between one and six teeth	Not recorded
Hypoplastic frontal sinuses	Not recorded
Long, narrow head	Not recorded

Abnormality of the eye

Trait	How often it is seen
Corneal dystrophy	Sometimes (5–29%)
Cross-eyed	Sometimes (5–29%)
Cat eye	Rarely (1–4%)
Astigmatism	Not recorded
Pigmentary retinopathy	Not recorded
Wide-set eyes	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Diminished deep tendon reflex	Very often (80–99%)
High pitched voice	Very often (80–99%)
Intellectual disability, mild	Sometimes (5–29%)
Ventriculomegaly	Sometimes (5–29%)
Difficulty articulating speech	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Pericardial constriction	Often (30–79%)
Enlarged heart	Sometimes (5–29%)
Cardiac failure	Not recorded
Myocardial fibrosis	Not recorded

Growth abnormality

Trait	How often it is seen
Growth delay	Very often (80–99%)
Prenatal growth deficiency	Very often (80–99%)
Short stature	Very often (80–99%)
Wasting syndrome	Very often (80–99%)

Abnormality of the digestive system

Trait	How often it is seen
Enlarged liver	Very often (80–99%)
Accumulation of fluid in the abdomen	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Often (30–79%)
Thickened cortex of long bones	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Single transverse palmar crease	Rarely (1–4%)

Abnormality of the genitourinary system

Trait	How often it is seen
Nephroblastoma	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Recurrent chest infections	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
port-wine stain	Often (30–79%)

Abnormality of the voice

Trait	How often it is seen
Weak voice	Very often (80–99%)

Laboratory abnormality

Trait	How often it is seen
Hydrops fetalis	Rarely (1–4%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TRIM37 and how often each is seen. Find out more at hpo.jax.org.

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