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Gene

WNT2B

Wnt family member 2B

Summary

Cytogenetic location
1p13.2
Coordinates
Chromosome 1: 112,508,965–112,530,165 (GRCh38)
Exons
5 exons across 21.2 kb
Protein
391 amino acids
Also known as
XWNT2
Previous symbols
WNT13
MANE Select transcript
ENST00000369684.5NM_024494.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Congenital Diarrhoeas & Enteropathies

    • Congenital diarrhoea

      Inherited conditions, including congenital chloride diarrhoea (SLC26A3), microvillus inclusion disease (MYO5B), tufting enteropathy (EPCAM) and congenital sodium diarrhoea (SPINT2, SLC9A3), that cause chronic diarrhoea from early infancy.

      • 2 GenCC submitters rate it definitive or strong
      What knowing changes

      A specific diagnosis directs treatment such as electrolyte replacement for chloride diarrhoea, or early planning for parenteral nutrition or intestinal transplant in microvillus inclusion disease and tufting enteropathy.

How WNT2B is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 1, with a bracket where WNT2B sits. WNT2B and 9 genes near it on chromosome 1, from 112,019,565 to 113,019,564.Chromosome 11p13.2p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44112.2 Mb112.4 Mb112.6 Mb112.8 Mb113 MbCTTNBP2NL: 112,396,198–112,463,456, forward strandCTTNBP2NLWNT2B: 112,508,965–112,530,165, forward strandWNT2BST7L: 112,523,473–112,620,825, reverse strandST7LCAPZA1: 112,619,173–112,672,747, forward strandCAPZA1MOV10: 112,673,141–112,702,415, forward strandMOV10RHOC: 112,699,765–112,707,897, reverse strandRHOC: 112,702,614–112,711,433, reverse strandPPM1J: 112,709,994–112,715,502, reverse strandPPM1JTAFA3: 112,718,881–112,729,076, forward strandSLC16A1: 112,904,043–112,957,593, reverse strandSLC16A1Diagram of WNT2B: 5 exons on the forward strand of chromosome 1Exon 2: 1 known disease-causing siteExon 3: 1 known disease-causing siteExon 4: 1 known disease-causing siteExon 1: 112,508,965–112,509,444, 480 basesExon 2: 112,514,874–112,515,094, 221 basesExon 3: 112,516,140–112,516,417, 278 basesExon 4: 112,517,121–112,517,385, 265 basesExon 5: 112,520,280–112,530,165, 9,886 bases123455′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 11.1 kb of the gene's 21.2 kb; 1,176 of those bases code for the protein.

How a genome test reads WNT2B

3

positions in WNT2B where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 21.2 kb of WNT2B, introns included, not only the 11.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). WNT2B gene: Wnt family member 2B. Retrieved 17 October 2026, from https://dantelabs.com/genes/wnt2b

Vancouver

Dante Labs. WNT2B gene: Wnt family member 2B [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/wnt2b

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