Traits

Traits linked to RNF31

ring finger protein 31

The Human Phenotype Ontology links 29 traits to RNF31, by body system: features seen in people with one of the gene's rare conditions.

RNF31

Abnormality of the immune system

Trait	How often it is seen
Decreased immune function	Always
Partial absence of specific antibody response to protein-conjugated Haemophilus influenzae type b vaccine	Always
Partial absence of specific antibody response to unconjugated pneumococcus polysaccharide	Always
Recurrent bacterial infections	Always
Recurrent viral infections	Always
Superficial dermal perivascular inflammatory infiltrate	Always
Eczema	Often (30–79%)

Laboratory abnormality

Trait	How often it is seen
Elevated circulating C-reactive protein concentration	Always
Elevated circulating haptoglobin concentration	Always
Episodic fever	Always
High ESR	Always
Low albumin	Always

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased memory T cell proportion	Always
Low number of red blood cells or hemoglobin	Often (30–79%)
Low T cell count	Often (30–79%)

Abnormal cellular phenotype

Trait	How often it is seen
Decreased antigen-specific T cell proliferation	Always
Decreased circulating IgG concentration	Often (30–79%)

Abnormality of limbs

Trait	How often it is seen
Clubbing of fingers and toes	Often (30–79%)
Lower limb muscle weakness	Often (30–79%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Increased spleen size	Always
Intestinal lymphangiectasia	Often (30–79%)

Abnormality of the digestive system

Trait	How often it is seen
Intermittent diarrhea	Always
Candida esophagitis	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Fatty replacement of skeletal muscle	Always
Muscle degeneration	Often (30–79%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Neonatal omphalitis	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Warts	Often (30–79%)

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Often (30–79%)

Growth abnormality

Trait	How often it is seen
Growth delay as children	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to RNF31 and how often each is seen. Find out more at hpo.jax.org.

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