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Gene

OTOGL

otogelin like

Summary

Cytogenetic location
12q21.31
Coordinates
Chromosome 12: 80,099,537–80,380,880 (GRCh38)
Exons
59 exons across 281.3 kb
Protein
2,353 amino acids
Also known as
FLJ90579
Previous symbols
C12orf64
MANE Select transcript
ENST00000547103.7NM_001378609.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

    • Hearing Loss and Deafness

      • Nonsyndromic Genetic Hearing Loss

        One of 97 genes linked to it

        Inherited hearing loss without other medical features, including the common recessive forms caused by GJB2, OTOF, SLC26A4, STRC and many other genes, as well as dominant, X-linked and mitochondrial forms.

        • ClinGen rates the link definitive
        • 5 GenCC submitters rate it definitive or strong
        What knowing changes

        Knowing the genetic cause can guide hearing support and cochlear implant decisions, gene-therapy trial eligibility (for example OTOF) and family counselling.

    How OTOGL is laid out

    • Coding sequence
    • Untranslated region
    • Intron
    • Direction of transcription
    • Known disease-causing sites
    • Stretches short reads find hard
    Chromosome 12, with a bracket where OTOGL sits. OTOGL and 4 genes near it on chromosome 12, from 79,740,209 to 80,740,208.Chromosome 1212q21.31p13.33p13.32p13.31p13.2p13.1p12.3p12.2p12.1p11.23p11.22p11.21p11.1q11q12q13.11q13.12q13.13q13.2q13.3q14.1q14.2q14.3q15q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.11q24.12q24.13q24.21q24.22q24.23q24.31q24.32q24.3379.8 Mb80 Mb80.2 Mb80.4 Mb80.6 MbPPP1R12A: 79,772,140–79,935,460, reverse strandPPP1R12AOTOGL: 80,099,537–80,380,880, forward strandOTOGLPTPRQ: 80,402,178–80,680,273, forward strandPTPRQMYF6: 80,707,534–80,709,670, forward strandMYF6MYF5: 80,716,906–80,719,671, forward strandMYF5Diagram of OTOGL: 59 exons on the forward strand of chromosome 12Exon 2: 2 known disease-causing sitesExon 9: 1 known disease-causing siteExon 10: 3 known disease-causing sitesExon 11: 1 known disease-causing siteExon 12: 1 known disease-causing siteExon 14: 1 known disease-causing siteExon 16: 1 known disease-causing siteExon 18: 1 known disease-causing siteExon 19: 1 known disease-causing siteExon 21: 1 known disease-causing siteExon 25: 1 known disease-causing siteExon 26: 3 known disease-causing sitesExon 27: 1 known disease-causing siteExon 28: 4 known disease-causing sitesExon 29: 1 known disease-causing siteExon 34: 2 known disease-causing sitesExon 36: 1 known disease-causing siteExon 37: 1 known disease-causing siteExon 39: 2 known disease-causing sitesExon 43: 3 known disease-causing sitesExon 44: 1 known disease-causing siteExon 46: 1 known disease-causing siteExon 47: 1 known disease-causing siteExon 50: 1 known disease-causing siteExon 51: 2 known disease-causing sitesExon 54: 3 known disease-causing sitesExon 55: 1 known disease-causing siteExon 56: 1 known disease-causing siteExon 58: 1 known disease-causing siteExon 1: 80,099,537–80,099,605, 69 basesExon 2: 80,209,413–80,209,510, 98 basesExon 3: 80,210,847–80,210,886, 40 basesExon 4: 80,211,949–80,211,997, 49 basesExon 5: 80,217,598–80,217,664, 67 basesExon 6: 80,219,814–80,219,912, 99 basesExon 7: 80,222,091–80,222,245, 155 basesExon 8: 80,229,257–80,229,378, 122 basesExon 9: 80,232,892–80,233,097, 206 basesExon 10: 80,238,851–80,238,978, 128 basesExon 11: 80,239,333–80,239,439, 107 basesExon 12: 80,251,693–80,251,799, 107 basesExon 13: 80,252,076–80,252,201, 126 basesExon 14: 80,253,466–80,253,574, 109 basesExon 15: 80,254,524–80,254,570, 47 basesExon 16: 80,255,040–80,255,185, 146 basesExon 17: 80,256,337–80,256,460, 124 basesExon 18: 80,257,825–80,258,002, 178 basesExon 19: 80,261,969–80,262,093, 125 basesExon 20: 80,265,001–80,265,210, 210 basesExon 21: 80,266,451–80,266,616, 166 basesExon 22: 80,267,253–80,267,327, 75 basesExon 23: 80,270,102–80,270,154, 53 basesExon 24: 80,271,648–80,271,810, 163 basesExon 25: 80,278,168–80,278,275, 108 basesExon 26: 80,279,028–80,279,166, 139 basesExon 27: 80,296,827–80,296,961, 135 basesExon 28: 80,302,634–80,302,783, 150 basesExon 29: 80,305,576–80,305,695, 120 basesExon 30: 80,310,611–80,310,727, 117 basesExon 31: 80,313,476–80,313,632, 157 basesExon 32: 80,314,305–80,314,331, 27 basesExon 33: 80,318,546–80,318,713, 168 basesExon 34: 80,320,422–80,320,700, 279 basesExon 35: 80,323,723–80,323,840, 118 basesExon 36: 80,328,665–80,328,744, 80 basesExon 37: 80,329,051–80,329,119, 69 basesExon 38: 80,333,005–80,333,078, 74 basesExon 39: 80,335,963–80,336,140, 178 basesExon 40: 80,336,413–80,336,555, 143 basesExon 41: 80,336,797–80,336,820, 24 basesExon 42: 80,336,912–80,337,004, 93 basesExon 43: 80,339,075–80,339,264, 190 basesExon 44: 80,341,948–80,342,162, 215 basesExon 45: 80,352,295–80,352,436, 142 basesExon 46: 80,353,325–80,353,510, 186 basesExon 47: 80,355,736–80,355,948, 213 basesExon 48: 80,356,416–80,356,520, 105 basesExon 49: 80,356,807–80,356,914, 108 basesExon 50: 80,358,248–80,358,349, 102 basesExon 51: 80,358,671–80,358,775, 105 basesExon 52: 80,358,860–80,358,900, 41 basesExon 53: 80,366,574–80,366,637, 64 basesExon 54: 80,367,561–80,367,739, 179 basesExon 55: 80,368,205–80,368,309, 105 basesExon 56: 80,370,570–80,370,689, 120 basesExon 57: 80,372,019–80,372,064, 46 basesExon 58: 80,377,123–80,377,202, 80 basesExon 59: 80,377,848–80,380,880, 3,033 bases11020304050595′3′

    Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

    Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

    Nearby genes from Ensembl release 116, on GRCh38.

    Exons make up 10 kb of the gene's 281.3 kb; 7,062 of those bases code for the protein.

    How a genome test reads OTOGL

    60

    positions in OTOGL where ClinVar classes a change as pathogenic or likely pathogenic

    None of them falls in a region short reads find hard.

    A whole genome covers all 281.3 kb of OTOGL, introns included, not only the 10 kb of exons.

    Where this comes from

    • HGNC: the gene's symbol, name, other symbols and location.
    • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
    • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
    • The ACMG secondary findings list, SF v3.2.
    • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
    • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
    • Data release 2026.10.16-c6eea6bf.

    Cite this page

    APA

    Dante Labs. (n.d.). OTOGL gene: otogelin like. Retrieved 17 October 2026, from https://dantelabs.com/genes/otogl

    Vancouver

    Dante Labs. OTOGL gene: otogelin like [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/otogl

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