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Gene

MT-TP

mitochondrially encoded tRNA-Pro (CCN)

Summary

Cytogenetic location
mitochondria
Inheritance
Mitochondrial
Also known as
trnP
Previous symbols
MTTP
Locus type
RNA, transfer

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Primary Mitochondrial Disease

    • MERRF SyndromeMitochondrial

      Usually caused by variants in mitochondrial DNA such as m.8344A>G, which can cause muscle jerks (myoclonus), seizures, balance problems and muscle weakness.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Knowing guides seizure treatment choices and monitoring of heart and hearing.

Broader groupings

  • Epilepsy (Full Panel)

    • Epilepsy

      One of 171 genes linked to it

      A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

Mitochondrial
The change is in the mitochondria's own DNA, which children inherit from their mother alone. A mother passes it on to all of her children, in amounts that can vary; a father passes it on to none.

How a genome test reads MT-TP

1

position in MT-TP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). MT-TP gene: mitochondrially encoded tRNA-Pro (CCN). Retrieved 16 October 2026, from https://dantelabs.com/genes/mt-tp

Vancouver

Dante Labs. MT-TP gene: mitochondrially encoded tRNA-Pro (CCN) [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/mt-tp

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