Traits

Traits linked to MAG

myelin associated glycoprotein

The Human Phenotype Ontology links 34 traits to MAG, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Abnormal pyramidal sign	Always
Babinski sign	Always
Global developmental delay	Always
Impaired distal vibration sensation	Always
Increased reflexes	Always
Lack of coordination of movement	Always
Impaired vibratory sensation	Very often (80–99%)
Intellectual disability	Very often (80–99%)
Decreased reflex response	Often (30–79%)
Loss of ability to walk	Often (30–79%)
Titubation	Sometimes (5–29%)
Ventriculomegaly	Sometimes (5–29%)
Cognitive impairment	Not recorded
Corpus callosum atrophy	Not recorded
Degeneration of cerebellum	Not recorded
Peripheral neuropathy	Not recorded

Abnormality of the musculoskeletal system

Trait	How often it is seen
Distal lower limb amyotrophy	Always
Involuntary muscle stiffness, contraction, or spasm	Always
Low muscle tone	Always
Low muscle tone, in neonatal onset	Always
Spastic dysarthria	Always
Spastic paraparesis	Always
Spastic walk	Always
Spastic paraplegia	Very often (80–99%)
Generalized decreased muscle tone	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Astigmatism	Always
Decreased clarity of vision	Always
Farsightedness	Always
Involuntary, rapid, rhythmic eye movements	Always
Glaucoma	Often (30–79%)
Temporal optic disc pallor	Often (30–79%)
Optic atrophy	Not recorded

Abnormality of limbs

Trait	How often it is seen
Areflexia of lower limbs	Not recorded
Hyporeflexia of lower limbs	Not recorded

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to MAG and how often each is seen. Find out more at hpo.jax.org.

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