Trait

Increased circulating T4 concentration

An elevation above the normal concentration of thyroxine in the blood. Thyroxine (also known as T4) is the main hormone secreted by the thyroid gland into the blood. It can be converted into the active form triiodothyronine (also known as T3).

HPO HP:0031506

Also called: Increased circulating T4 level, Increased circulating thyroxine level
Body system: Abnormality of the endocrine system

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4 genes linked to Increased circulating T4 concentration

Changes in these genes cause rare conditions in which Increased circulating T4 concentration is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.

Gene	How often it is seen	Conditions
KCNJ18potassium inwardly rectifying channel subfamily J member 18	Always	In 1 condition
SECISBP2SECIS binding protein 2	Always	In 2 conditions
THRBthyroid hormone receptor beta	Always	In 1 condition
TSHRthyroid stimulating hormone receptor	Always	In 2 conditions

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Broader traits

Abnormal circulating T4 concentration

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
Data release 2026.10.16-c6eea6bf.

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