Traits

Traits linked to INTS11

integrator complex subunit 11

The Human Phenotype Ontology links 42 traits to INTS11, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Agenesis of corpus callosum	Always
Brain degeneration	Always
Degeneration of cerebellum	Always
Degeneration of cerebrum	Always
Delayed CNS myelination	Always
Delayed speech and language development	Always
Dilated fourth ventricle	Always
Epilepsy	Always
Hyperintensity of cerebral white matter on MRI	Always
Intellectual disability, mild	Always
Intellectual disability, severe	Always
Leukoencephalopathy	Always
Motor delay	Always
Pontocerebellar atrophy	Always
Severe global developmental delay	Always
Simplified gyral pattern	Always
Small cerebellum	Always
Ventriculomegaly	Always

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always
Bifid uvula	Always
Coarse facial features	Always
Deformity of the skull	Always
Eye folds	Always
Narrow palate	Always
Prominent area between the eyebrows	Always
Receding chin	Always
Sloping forehead	Always
Small forehead	Always
Thin red part of the upper lip	Always
Triangular face	Always
Wide mouth	Always
Wide nose	Always

Abnormality of the eye

Trait	How often it is seen
Astigmatism	Always
Breakdown of light-sensitive cells in back of eye	Always
Close sighted	Always
Cross-eyed	Always
Optic atrophy	Always
Wide-set eyes	Always

Abnormality of prenatal development or birth

Trait	How often it is seen
Premature birth	Always

Abnormality of the ear

Trait	How often it is seen
Low-set ears	Always

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Always

Growth abnormality

Trait	How often it is seen
Prenatal growth deficiency	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to INTS11 and how often each is seen. Find out more at hpo.jax.org.

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