Traits

Traits linked to GRB10

growth factor receptor bound protein 10

The Human Phenotype Ontology links 59 traits to GRB10, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Little lower jaw	Very often (80–99%)
Abnormal facial shape	Often (30–79%)
Decreased volume of lip	Often (30–79%)
Downturned corners of mouth	Often (30–79%)
Prominent forehead	Often (30–79%)
Relatively large head	Often (30–79%)
Triangular face	Often (30–79%)
Decreased size of tooth	Sometimes (5–29%)
Deep bite	Sometimes (5–29%)
Delayed closure of the soft spot on the skull	Sometimes (5–29%)
Dental crowding	Sometimes (5–29%)
Frontal bossing	Sometimes (5–29%)
High, narrow palate	Sometimes (5–29%)
Narrow mouth	Sometimes (5–29%)
Pierre-Robin sequence	Sometimes (5–29%)
Short chin	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Delayed speech and language development	Often (30–79%)
Global developmental delay	Often (30–79%)
Motor delay	Often (30–79%)
High pitched voice	Sometimes (5–29%)
Obstructive sleep apnea	Sometimes (5–29%)
Oral aversion	Sometimes (5–29%)
Specific learning disability	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Curvature of digit	Often (30–79%)
Short fingers or toes	Often (30–79%)
Webbed fingers or toes	Often (30–79%)
Curvature of little finger	Sometimes (5–29%)
Left and right leg differ in length or width	Sometimes (5–29%)
Narrow joint spaces of the elbow	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Acid reflux	Often (30–79%)
Feeding difficulties in infancy	Often (30–79%)
Constipation	Sometimes (5–29%)
Inflammation of the esophagus	Sometimes (5–29%)
Poor appetite	Sometimes (5–29%)
Vomiting	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Growth delay as children	Very often (80–99%)
Prenatal growth deficiency	Very often (80–99%)
Faltering weight	Often (30–79%)
Small for gestational age	Often (30–79%)
Uneven or disproportionate growth of one body part compared to another	Often (30–79%)
Severe prenatal growth deficiency	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormality of the genitourinary system	Sometimes (5–29%)
Hypospadias	Sometimes (5–29%)
Undescended testes	Sometimes (5–29%)
Horseshoe kidney	Rarely (1–4%)
Renal dysplasia	Rarely (1–4%)

Abnormality of the endocrine system

Trait	How often it is seen
Decreased response to growth hormone stimulation test	Sometimes (5–29%)
Early onset of puberty	Sometimes (5–29%)
Premature adrenarche	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Delayed bone maturation	Very often (80–99%)
Decreased muscle mass	Sometimes (5–29%)
Scoliosis	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Excessive sweating	Sometimes (5–29%)
Shoulder dimple	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Low blood sugar when fasting	Often (30–79%)
Body fails to respond to insulin	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormality of the heart	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Abnormality of the outer ear	Often (30–79%)

Abnormality of the respiratory system

Trait	How often it is seen
Aspiration	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to GRB10 and how often each is seen. Find out more at hpo.jax.org.

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