CYP2C19

CYP2C19 a léky

• Antidepressant, stomach-acid & clopidogrel response

  Pharmacogenomics

  CYP2C19 clears several common antidepressants (citalopram, escitalopram, sertraline and some tricyclics), the proton-pump inhibitors used for reflux and ulcers, and the antifungal voriconazole — and it activates the antiplatelet clopidogrel into its working form. Activity ranges from poor to ultrarapid depending on which alleles you carry.

  • Most relevant if you are prescribed clopidogrel after a stent, heart attack, or stroke — poor metabolisers may get little protection from it.
  • If you start citalopram, escitalopram or sertraline, this result can guide the starting dose, and can help explain side effects or a weak response.
  • Omeprazole, lansoprazole and pantoprazole may work less well in rapid and ultrarapid metabolisers; poor metabolisers on long-term treatment may manage on a lower dose.
  • Also relevant to voriconazole, amitriptyline and other tricyclic antidepressants, and the anti-seizure drug clobazam.

  Alely, které report čte

  • *4No function
  • *1Normal function
  • *17Increased function
  • *3No function
  • *2No function

  Výsledky, které popisuje CPIC

  • Poor Metabolizer
  • Intermediate Metabolizer
  • Indeterminate
  • Likely Intermediate Metabolizer
  • Rapid Metabolizer
  • Normal Metabolizer
  • Ultrarapid Metabolizer
  • Likely Poor Metabolizer

  Lék	Úroveň CPIC	Směrnice
  amitriptyline	A	CYP2D6, CYP2C19 and Tricyclic Antidepressants
  citalopram	A	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  clopidogrel	A	CYP2C19 and Clopidogrel
  escitalopram	A	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  lansoprazole	A	CYP2C19 and Proton Pump Inhibitors
  omeprazole	A	CYP2C19 and Proton Pump Inhibitors
  pantoprazole	A	CYP2C19 and Proton Pump Inhibitors
  sertraline	A	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  voriconazole	A	CYP2C19 and Voriconazole
  brivaracetam	B
  clomipramine	B	CYP2D6, CYP2C19 and Tricyclic Antidepressants
  dexlansoprazole	B	CYP2C19 and Proton Pump Inhibitors
  doxepin	B	CYP2D6, CYP2C19 and Tricyclic Antidepressants
  imipramine	B	CYP2D6, CYP2C19 and Tricyclic Antidepressants
  trimipramine	B	CYP2D6, CYP2C19 and Tricyclic Antidepressants

  Zobrazit 12 dalších léků

  Lék	Úroveň CPIC	Směrnice
  carisoprodol	B/C
  clobazam	B/C
  diazepam	B/C
  duloxetine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  esomeprazole	C	CYP2C19 and Proton Pump Inhibitors
  flibanserin	C
  fluoxetine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  fluvoxamine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  paroxetine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  rabeprazole	C	CYP2C19 and Proton Pump Inhibitors
  venlafaxine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  vortioxetine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants

  Calls the common *2, *3, *4 and *17 alleles. CYP2C19 lacks the copy-number complexity of CYP2D6, so common-allele calling is well supported — but rare alleles are not assessed.

Jak je CYP2C19 uspořádán

Exony tvoří 4,1 kb z 92,9 kb genu; 1 473 těchto bází kódují protein.

Externí odkazy

Odkud údaje pocházejí

• HGNC: symbol genu, název, další symboly a umístění.
• MANE Select v1.5, z NCBI a EMBL-EBI: transkript, jeho exony a kódující sekvence.
• CPIC a PharmGKB: alely, výsledky a léky.

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