CYP2C19

CYP2C19 és a gyógyszerek

• Antidepressant, stomach-acid & clopidogrel response

  Pharmacogenomics

  CYP2C19 clears several common antidepressants (citalopram, escitalopram, sertraline and some tricyclics), the proton-pump inhibitors used for reflux and ulcers, and the antifungal voriconazole — and it activates the antiplatelet clopidogrel into its working form. Activity ranges from poor to ultrarapid depending on which alleles you carry.

  • Most relevant if you are prescribed clopidogrel after a stent, heart attack, or stroke — poor metabolisers may get little protection from it.
  • If you start citalopram, escitalopram or sertraline, this result can guide the starting dose, and can help explain side effects or a weak response.
  • Omeprazole, lansoprazole and pantoprazole may work less well in rapid and ultrarapid metabolisers; poor metabolisers on long-term treatment may manage on a lower dose.
  • Also relevant to voriconazole, amitriptyline and other tricyclic antidepressants, and the anti-seizure drug clobazam.

  A jelentés által olvasott allélok

  • *4No function
  • *1Normal function
  • *17Increased function
  • *3No function
  • *2No function

  A CPIC által leírt eredmények

  • Poor Metabolizer
  • Intermediate Metabolizer
  • Indeterminate
  • Likely Intermediate Metabolizer
  • Rapid Metabolizer
  • Normal Metabolizer
  • Ultrarapid Metabolizer
  • Likely Poor Metabolizer

  Gyógyszer	CPIC szint	Irányelv
  amitriptyline	A	CYP2D6, CYP2C19 and Tricyclic Antidepressants
  citalopram	A	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  clopidogrel	A	CYP2C19 and Clopidogrel
  escitalopram	A	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  lansoprazole	A	CYP2C19 and Proton Pump Inhibitors
  omeprazole	A	CYP2C19 and Proton Pump Inhibitors
  pantoprazole	A	CYP2C19 and Proton Pump Inhibitors
  sertraline	A	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  voriconazole	A	CYP2C19 and Voriconazole
  brivaracetam	B
  clomipramine	B	CYP2D6, CYP2C19 and Tricyclic Antidepressants
  dexlansoprazole	B	CYP2C19 and Proton Pump Inhibitors
  doxepin	B	CYP2D6, CYP2C19 and Tricyclic Antidepressants
  imipramine	B	CYP2D6, CYP2C19 and Tricyclic Antidepressants
  trimipramine	B	CYP2D6, CYP2C19 and Tricyclic Antidepressants

  Még 12 gyógyszer megjelenítése

  Gyógyszer	CPIC szint	Irányelv
  carisoprodol	B/C
  clobazam	B/C
  diazepam	B/C
  duloxetine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  esomeprazole	C	CYP2C19 and Proton Pump Inhibitors
  flibanserin	C
  fluoxetine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  fluvoxamine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  paroxetine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  rabeprazole	C	CYP2C19 and Proton Pump Inhibitors
  venlafaxine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants
  vortioxetine	C	CYP2D6, CYP2C19, CYP2B6, SLC6A4, HTR2A and Serotonin Reuptake Inhibitor Antidepressants

  Calls the common *2, *3, *4 and *17 alleles. CYP2C19 lacks the copy-number complexity of CYP2D6, so common-allele calling is well supported — but rare alleles are not assessed.

A CYP2C19 felépítése

Az exonok a gén 92,9 kb-jából 4,1 kb-ot tesznek ki; ezek közül 1473 bázis kódolja a fehérjét.

Külső hivatkozások

Honnan származnak az adatok

• HGNC: a gén szimbóluma, neve, egyéb szimbólumai és elhelyezkedése.
• MANE Select v1.5, az NCBI-tól és az EMBL-EBI-tól: a transzkriptum, exonjai és kódoló szekvenciája.
• CPIC és PharmGKB: az allélok, az eredmények és a gyógyszerek.

Az oldal idézése