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Gene

AXIN2

axin 2

Summary

Cytogenetic location
17q24.1
Coordinates
Chromosome 17: 65,528,563–65,561,648 (GRCh38)
Exons
11 exons across 33.1 kb
Protein
843 amino acids
Inheritance
Autosomal dominant
Also known as
MGC126582, DKFZp781B0869
MANE Select transcript
ENST00000307078.10NM_004655.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Colorectal Cancer & Polyposis

    • Oligodontia-colorectal cancer syndromeAutosomal dominant

      AXIN2 variants causing missing permanent teeth (oligodontia) together with colorectal polyps and an increased risk of colorectal cancer.

      • ClinGen rates the link definitive
      • 4 GenCC submitters rate it definitive or strong
      What knowing changes

      Colonoscopy surveillance and dental care; relatives can be offered testing.

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How AXIN2 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 17, with a bracket where AXIN2 sits. AXIN2 and 4 genes near it on chromosome 17, from 65,045,106 to 66,045,105.Chromosome 1717q24.1p13.3p13.2p13.1p12p11.2p11.1q11.1q11.2q12q21.1q21.2q21.31q21.32q21.33q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.365.2 Mb65.4 Mb65.6 Mb65.8 Mb66 MbGNA13: 65,009,289–65,056,839, reverse strandGNA13RGS9: 65,100,812–65,227,703, forward strandRGS9AXIN2: 65,528,563–65,561,648, reverse strandAXIN2: 65,538,102–65,641,033, reverse strandCEP112: 65,635,537–66,192,251, reverse strandCEP112Diagram of AXIN2: 11 exons on the reverse strand of chromosome 17Exon 10: 8 known disease-causing sitesExon 9: 5 known disease-causing sitesExon 8: 25 known disease-causing sitesExon 6: 34 known disease-causing sitesExon 5: 5 known disease-causing sitesExon 4: 7 known disease-causing sitesExon 3: 3 known disease-causing sitesExon 2: 38 known disease-causing sitesExon 11: 65,528,563–65,530,102, 1,540 basesExon 10: 65,533,912–65,534,079, 168 basesExon 9: 65,535,626–65,535,721, 96 basesExon 8: 65,536,320–65,536,553, 234 basesExon 7: 65,536,869–65,537,063, 195 basesExon 6: 65,537,324–65,537,835, 512 basesExon 5: 65,538,203–65,538,343, 141 basesExon 4: 65,541,455–65,541,557, 103 basesExon 3: 65,549,520–65,549,660, 141 basesExon 2: 65,557,806–65,558,736, 931 basesExon 1: 65,561,450–65,561,648, 199 bases11109876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 4.3 kb of the gene's 33.1 kb; 2,532 of those bases code for the protein.

How a genome test reads AXIN2

142

positions in AXIN2 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 33.1 kb of AXIN2, introns included, not only the 4.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). AXIN2 gene: axin 2. Retrieved 16 October 2026, from https://dantelabs.com/genes/axin2

Vancouver

Dante Labs. AXIN2 gene: axin 2 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/axin2

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