{
  "url": "https://dantelabs.com/traits/adrenal-insufficiency",
  "trait": {
    "bundleId": "2026.10.19-9814e911",
    "release": "2026-09-01",
    "slug": "adrenal-insufficiency",
    "id": "HP:0000846",
    "name": "Adrenal insufficiency",
    "definition": "Insufficient production of steroid hormones (primarily cortisol) by the adrenal glands.",
    "synonyms": [
      "Hypoadrenalism"
    ],
    "systems": [
      {
        "slug": "abnormality-of-the-endocrine-system",
        "name": "Abnormality of the endocrine system",
        "url": "https://dantelabs.com/traits/abnormality-of-the-endocrine-system"
      }
    ],
    "broader": [
      {
        "slug": "abnormality-of-adrenal-physiology",
        "name": "Abnormality of adrenal physiology",
        "url": "https://dantelabs.com/traits/abnormality-of-adrenal-physiology"
      }
    ],
    "narrower": [
      {
        "slug": "primary-adrenal-insufficiency",
        "name": "Primary adrenal insufficiency",
        "genes": 22,
        "url": "https://dantelabs.com/traits/primary-adrenal-insufficiency"
      },
      {
        "slug": "central-adrenal-insufficiency",
        "name": "Central adrenal insufficiency",
        "genes": 16,
        "url": "https://dantelabs.com/traits/central-adrenal-insufficiency"
      }
    ],
    "genes": [
      {
        "slug": "gk",
        "symbol": "GK",
        "hgnc": "HGNC:4289",
        "name": "glycerol kinase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gk"
      },
      {
        "slug": "kdm6b",
        "symbol": "KDM6B",
        "hgnc": "HGNC:29012",
        "name": "lysine demethylase 6B",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/kdm6b"
      },
      {
        "slug": "lipa",
        "symbol": "LIPA",
        "hgnc": "HGNC:6617",
        "name": "lipase A, lysosomal acid type",
        "frequency": "obligate",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/lipa"
      },
      {
        "slug": "mc2r",
        "symbol": "MC2R",
        "hgnc": "HGNC:6930",
        "name": "melanocortin 2 receptor",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mc2r"
      },
      {
        "slug": "mcm4",
        "symbol": "MCM4",
        "hgnc": "HGNC:6947",
        "name": "minichromosome maintenance complex component 4",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mcm4"
      },
      {
        "slug": "mrap",
        "symbol": "MRAP",
        "hgnc": "HGNC:1304",
        "name": "melanocortin 2 receptor accessory protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrap"
      },
      {
        "slug": "mrps25",
        "symbol": "MRPS25",
        "hgnc": "HGNC:14511",
        "name": "mitochondrial ribosomal protein S25",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mrps25"
      },
      {
        "slug": "ndufaf5",
        "symbol": "NDUFAF5",
        "hgnc": "HGNC:15899",
        "name": "NADH:ubiquinone oxidoreductase complex assembly factor 5",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/ndufaf5"
      },
      {
        "slug": "nnt",
        "symbol": "NNT",
        "hgnc": "HGNC:7863",
        "name": "nicotinamide nucleotide transhydrogenase",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nnt"
      },
      {
        "slug": "samd9",
        "symbol": "SAMD9",
        "hgnc": "HGNC:1348",
        "name": "sterile alpha motif domain containing 9",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/samd9"
      },
      {
        "slug": "star",
        "symbol": "STAR",
        "hgnc": "HGNC:11359",
        "name": "steroidogenic acute regulatory protein",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/star"
      },
      {
        "slug": "txnrd2",
        "symbol": "TXNRD2",
        "hgnc": "HGNC:18155",
        "name": "thioredoxin reductase 2",
        "frequency": "obligate",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/txnrd2"
      },
      {
        "slug": "aaas",
        "symbol": "AAAS",
        "hgnc": "HGNC:13666",
        "name": "aladin WD repeat nucleoporin",
        "frequency": "very-frequent",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/aaas"
      },
      {
        "slug": "gmppa",
        "symbol": "GMPPA",
        "hgnc": "HGNC:22923",
        "name": "GDP-mannose pyrophosphorylase A",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gmppa"
      },
      {
        "slug": "trappc11",
        "symbol": "TRAPPC11",
        "hgnc": "HGNC:25751",
        "name": "trafficking protein particle complex subunit 11",
        "frequency": "very-frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/trappc11"
      },
      {
        "slug": "aire",
        "symbol": "AIRE",
        "hgnc": "HGNC:360",
        "name": "autoimmune regulator",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aire"
      },
      {
        "slug": "nfs1",
        "symbol": "NFS1",
        "hgnc": "HGNC:15910",
        "name": "NFS1 cysteine desulfurase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nfs1"
      },
      {
        "slug": "por",
        "symbol": "POR",
        "hgnc": "HGNC:9208",
        "name": "cytochrome p450 oxidoreductase",
        "frequency": "frequent",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/por"
      },
      {
        "slug": "abcd1",
        "symbol": "ABCD1",
        "hgnc": "HGNC:61",
        "name": "ATP binding cassette subfamily D member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/abcd1"
      },
      {
        "slug": "aip",
        "symbol": "AIP",
        "hgnc": "HGNC:358",
        "name": "AHR interacting HSP90 co-chaperone",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/aip"
      },
      {
        "slug": "bcor",
        "symbol": "BCOR",
        "hgnc": "HGNC:20893",
        "name": "BCL6 corepressor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/bcor"
      },
      {
        "slug": "dhx37",
        "symbol": "DHX37",
        "hgnc": "HGNC:17210",
        "name": "DEAH-box helicase 37",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/dhx37"
      },
      {
        "slug": "fbxo22",
        "symbol": "FBXO22",
        "hgnc": "HGNC:13593",
        "name": "F-box protein 22",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/fbxo22"
      },
      {
        "slug": "gata4",
        "symbol": "GATA4",
        "hgnc": "HGNC:4173",
        "name": "GATA binding protein 4",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gata4"
      },
      {
        "slug": "gpr101",
        "symbol": "GPR101",
        "hgnc": "HGNC:14963",
        "name": "G protein-coupled receptor 101",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/gpr101"
      },
      {
        "slug": "hsd3b2",
        "symbol": "HSD3B2",
        "hgnc": "HGNC:5218",
        "name": "hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/hsd3b2"
      },
      {
        "slug": "map3k1",
        "symbol": "MAP3K1",
        "hgnc": "HGNC:6848",
        "name": "mitogen-activated protein kinase kinase kinase 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/map3k1"
      },
      {
        "slug": "nr0b1",
        "symbol": "NR0B1",
        "hgnc": "HGNC:7960",
        "name": "nuclear receptor subfamily 0 group B member 1",
        "frequency": "occasional",
        "diseases": 2,
        "url": "https://dantelabs.com/genes/nr0b1"
      },
      {
        "slug": "nr5a1",
        "symbol": "NR5A1",
        "hgnc": "HGNC:7983",
        "name": "nuclear receptor subfamily 5 group A member 1",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/nr5a1"
      },
      {
        "slug": "sox9",
        "symbol": "SOX9",
        "hgnc": "HGNC:11204",
        "name": "SRY-box transcription factor 9",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sox9"
      },
      {
        "slug": "sry",
        "symbol": "SRY",
        "hgnc": "HGNC:11311",
        "name": "sex determining region Y",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sry"
      },
      {
        "slug": "steap3",
        "symbol": "STEAP3",
        "hgnc": "HGNC:24592",
        "name": "STEAP3 metalloreductase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/steap3"
      },
      {
        "slug": "vamp7",
        "symbol": "VAMP7",
        "hgnc": "HGNC:11486",
        "name": "vesicle associated membrane protein 7",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/vamp7"
      },
      {
        "slug": "wt1",
        "symbol": "WT1",
        "hgnc": "HGNC:12796",
        "name": "WT1 transcription factor",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wt1"
      },
      {
        "slug": "wwox",
        "symbol": "WWOX",
        "hgnc": "HGNC:12799",
        "name": "WW domain containing oxidoreductase",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/wwox"
      },
      {
        "slug": "zfpm2",
        "symbol": "ZFPM2",
        "hgnc": "HGNC:16700",
        "name": "zinc finger protein, FOG family member 2",
        "frequency": "occasional",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/zfpm2"
      },
      {
        "slug": "hbb",
        "symbol": "HBB",
        "hgnc": "HGNC:4827",
        "name": "hemoglobin subunit beta",
        "frequency": "very-rare",
        "diseases": 3,
        "url": "https://dantelabs.com/genes/hbb"
      },
      {
        "slug": "herc2",
        "symbol": "HERC2",
        "hgnc": "HGNC:4868",
        "name": "HECT and RLD domain containing E3 ubiquitin protein ligase 2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/herc2"
      },
      {
        "slug": "magel2",
        "symbol": "MAGEL2",
        "hgnc": "HGNC:6814",
        "name": "MAGE family member L2",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/magel2"
      },
      {
        "slug": "mkrn3",
        "symbol": "MKRN3",
        "hgnc": "HGNC:7114",
        "name": "makorin ring finger protein 3",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/mkrn3"
      },
      {
        "slug": "npap1",
        "symbol": "NPAP1",
        "hgnc": "HGNC:1190",
        "name": "nuclear pore associated protein 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/npap1"
      },
      {
        "slug": "pwar1",
        "symbol": "PWAR1",
        "hgnc": "HGNC:30089",
        "name": "Prader Willi/Angelman region RNA 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pwar1"
      },
      {
        "slug": "pwrn1",
        "symbol": "PWRN1",
        "hgnc": "HGNC:33235",
        "name": "Prader-Willi region non-protein coding RNA 1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pwrn1"
      },
      {
        "slug": "saa1",
        "symbol": "SAA1",
        "hgnc": "HGNC:10513",
        "name": "serum amyloid A1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/saa1"
      },
      {
        "slug": "snord115-1",
        "symbol": "SNORD115-1",
        "hgnc": "HGNC:33020",
        "name": "small nucleolar RNA, C/D box 115-1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snord115-1"
      },
      {
        "slug": "snord116-1",
        "symbol": "SNORD116-1",
        "hgnc": "HGNC:33067",
        "name": "small nucleolar RNA, C/D box 116-1",
        "frequency": "very-rare",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/snord116-1"
      },
      {
        "slug": "cyp11a1",
        "symbol": "CYP11A1",
        "hgnc": "HGNC:2590",
        "name": "cytochrome P450 family 11 subfamily A member 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/cyp11a1"
      },
      {
        "slug": "lhx4",
        "symbol": "LHX4",
        "hgnc": "HGNC:21734",
        "name": "LIM homeobox 4",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/lhx4"
      },
      {
        "slug": "pex5",
        "symbol": "PEX5",
        "hgnc": "HGNC:9719",
        "name": "peroxisomal biogenesis factor 5",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex5"
      },
      {
        "slug": "pex6",
        "symbol": "PEX6",
        "hgnc": "HGNC:8859",
        "name": "peroxisomal biogenesis factor 6",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pex6"
      },
      {
        "slug": "pomc",
        "symbol": "POMC",
        "hgnc": "HGNC:9201",
        "name": "proopiomelanocortin",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/pomc"
      },
      {
        "slug": "prop1",
        "symbol": "PROP1",
        "hgnc": "HGNC:9455",
        "name": "PROP paired-like homeobox 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/prop1"
      },
      {
        "slug": "sgpl1",
        "symbol": "SGPL1",
        "hgnc": "HGNC:10817",
        "name": "sphingosine-1-phosphate lyase 1",
        "diseases": 1,
        "url": "https://dantelabs.com/genes/sgpl1"
      }
    ]
  }
}