Peer-reviewed · Data in Brief · 2021
Replicate whole-genome next-generation sequencing data derived from Caucasian donor saliva samples
This work provides a publicly available triplicate whole-genome sequencing dataset from saliva DNA of a single anonymous male donor, intended for testing bioinformatics pipelines. Across the three replicates, 81% of variants appeared in at least two samples, and the karyotype was 46,XY with no apparent copy-number variation.
Hansen & Nyvold
This work provides a publicly available triplicate whole-genome sequencing dataset from saliva DNA of a single anonymous male donor, intended for testing bioinformatics pipelines. Across the three replicates, 81% of variants appeared in at least two samples, and the karyotype was 46,XY with no apparent copy-number variation.
Dante Labs’ involvement
Dante Labs carried out the DNA extraction, quality control, library preparation and sequencing for this study as the sequencing provider for all three replicates. Saliva was collected by the research team from a single anonymous donor using GeneFiX Saliva DNA collection kits, and the samples were processed in separate batches at our facility in L'Aquila, Italy, over approximately one year. Sequencing was run on our Illumina NovaSeq 6000 platform, generating triplicate paired-end reads — 1.38 billion in total — with average depths aimed at 30x for two of the samples and 4x for the low-coverage sample, delivered to the research team as raw gzipped FASTQ files.
The authors also thank Dante Labs in the acknowledgements for extended assistance with data retrieval. The bioinformatic assessment described in the paper (alignment, variant calling and quality assessment) was carried out by the research team.
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