Traits

Traits linked to TNXB

tenascin XB

The Human Phenotype Ontology links 61 traits to TNXB, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the musculoskeletal system

Trait	How often it is seen
Double-Jointed	Always
Hypermobility of all joints	Very often (80–99%)
Back pain	Often (30–79%)
Joint subluxation	Often (30–79%)
Low muscle tone	Often (30–79%)
Multiple joint dislocation	Often (30–79%)
Muscle degeneration	Often (30–79%)
Muscle weakness	Often (30–79%)
Increased connective tissue	Sometimes (5–29%)
Muscle fiber splitting	Sometimes (5–29%)
Proximal neurogenic muscle weakness	Sometimes (5–29%)
Wasting of muscles near the body	Sometimes (5–29%)
Increased compartment pressure	Rarely (1–4%)

Abnormality of limbs

Trait	How often it is seen
Abnormal feet structure	Very often (80–99%)
Broad foot	Often (30–79%)
Bunion	Often (30–79%)
Dropped arches	Often (30–79%)
Short finger	Often (30–79%)
Short fingers or toes	Often (30–79%)
Short toe	Often (30–79%)
Curvature of digit	Sometimes (5–29%)
Fluid accumulation in lower limbs	Sometimes (5–29%)
Mallet finger	Sometimes (5–29%)
Hand muscle degeneration	Rarely (1–4%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Abnormal heart valve morphology	Sometimes (5–29%)
Bulge in wall of large artery that carries blood away from heart	Sometimes (5–29%)
Dilatation of an abdominal artery	Sometimes (5–29%)
Mitral valve prolapse	Sometimes (5–29%)
Stroke	Sometimes (5–29%)
Disease of the heart muscle	Rarely (1–4%)
Quadricuspid aortic valve	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Frequent urinary tract infections	Always
Duplicated collecting system	Often (30–79%)
Vesicoureteral reflux	Often (30–79%)
Sagging uterus	Sometimes (5–29%)
Absent kidney on one side	Not recorded
Atypical appearance of female genitals	Not recorded
Heart shaped uterus	Not recorded

Abnormality of the integument

Trait	How often it is seen
Hyperelastic skin	Always
Soft skin	Very often (80–99%)
Piezogenic pedal papules	Often (30–79%)
Poor wound healing	Often (30–79%)
Thin skin	Often (30–79%)
Stretch marks	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Bruising susceptibility	Always
Spontaneous hematomas	Very often (80–99%)
Bleeding post-delivery	Sometimes (5–29%)
Gastrointestinal bleeding	Sometimes (5–29%)
Subconjunctival hemorrhage	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Bowel diverticulosis	Sometimes (5–29%)
Intestinal perforation	Sometimes (5–29%)
Rectum protrudes through anus	Sometimes (5–29%)
Spontaneous esophageal perforation	Sometimes (5–29%)
Stomach hernia	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Damage to nerves that sense feeling	Often (30–79%)
Peripheral neuropathy	Often (30–79%)
Peripheral axonal neuropathy	Sometimes (5–29%)

Constitutional symptom

Trait	How often it is seen
Fatigue	Often (30–79%)
Joint pain	Often (30–79%)
Muscle ache	Sometimes (5–29%)

Abnormality of prenatal development or birth

Trait	How often it is seen
Premature rupture of membranes	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TNXB and how often each is seen. Find out more at hpo.jax.org.

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