Traits

Traits linked to TECPR2

tectonin beta-propeller repeat containing 2

The Human Phenotype Ontology links 28 traits to TECPR2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Absent reflexes	Always
Degeneration of cerebrum	Always
Global developmental delay	Always
Inability to coordinate movements when walking	Always
Intellectual disability	Always
Underdevelopment of part of brain called corpus callosum	Always
Difficulty articulating speech	Often (30–79%)
Grand mal seizures	Often (30–79%)
Lack of coordination of movement	Often (30–79%)
Degeneration of cerebellum	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always
Broad head shape	Always
Broad neck	Always
Decreased facial expressions	Always
Dental crowding	Always
Low frontal hairline	Always
Round face	Always
Short neck	Always
Full cheeks	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Always
Spastic walk	Always
Generalized decreased muscle tone	Often (30–79%)
Spastic paraplegia	Not recorded

Abnormality of the digestive system

Trait	How often it is seen
Acid reflux	Always

Abnormality of the immune system

Trait	How often it is seen
Recurrent respiratory infections	Very often (80–99%)

Abnormality of the respiratory system

Trait	How often it is seen
Central apnea	Always

Growth abnormality

Trait	How often it is seen
Short stature	Always

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TECPR2 and how often each is seen. Find out more at hpo.jax.org.

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