Traits

Traits linked to SLF2

SMC5/6 complex localization factor 2

The Human Phenotype Ontology links 32 traits to SLF2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Basilar invagination	Sometimes (5–29%)
Dental cavities	Sometimes (5–29%)
Downward slanting of the opening between the eyelids	Sometimes (5–29%)
High palate	Sometimes (5–29%)
Long face	Sometimes (5–29%)
Long philtrum	Sometimes (5–29%)
Prominent nose	Sometimes (5–29%)
Short chin	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Low muscle tone	Sometimes (5–29%)
Low muscle tone, in neonatal onset	Sometimes (5–29%)
Rounded lower back	Sometimes (5–29%)
Spasticity and rigidity of muscles	Sometimes (5–29%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased blood leukocyte number	Sometimes (5–29%)
Low number of red blood cells or hemoglobin	Sometimes (5–29%)
Low platelet count	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Birthmark	Often (30–79%)
Dry skin	Sometimes (5–29%)
Irregular hyperpigmentation	Sometimes (5–29%)

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Attention deficit	Sometimes (5–29%)
Autism spectrum disorder	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
An opening in the wall separating the top two chambers of the heart	Sometimes (5–29%)
Hole in heart wall separating two lower heart chambers	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Glue ear	Sometimes (5–29%)
Small ears	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Eczema	Sometimes (5–29%)
Recurrent infections	Sometimes (5–29%)

Abnormal cellular phenotype

Trait	How often it is seen
Decreased anti-CD3/28-induced T-cell proliferation	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Feeding difficulties	Often (30–79%)

Abnormality of the endocrine system

Trait	How often it is seen
Underactive thyroid	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Clouding of the lens of the eye	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Permanent enlargement of the airways of the lungs	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to SLF2 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test