Trait
Agammaglobulinemia
A lasting absence of total IgG and total IgA and total IgM in the blood circulation, whereby at most trace quantities can be measured.
Summary
- Also called
- Agammaglobulinaemia
Reference genomeGRCh38hg38
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Get my Genome Test27 genes linked to Agammaglobulinemia
Changes in these genes cause rare conditions in which Agammaglobulinemia is seen. Most people with this trait have none of those conditions, and a gene on this list says nothing about anyone's own genome.
| Gene | How often it is seen | Conditions |
|---|---|---|
| BTKBruton tyrosine kinase | Always | In 2 conditions |
| CARD11caspase recruitment domain family member 11 | Always | In 1 condition |
| CD79ACD79a molecule | Always | In 2 conditions |
| DCLRE1CDNA cross-link repair 1C | Always | In 1 condition |
| FNIP1folliculin interacting protein 1 | Always | In 1 condition |
| IRF4interferon regulatory factor 4 | Always | In 1 condition |
| RAG1recombination activating 1 | Always | In 1 condition |
| RAG2recombination activating 2 | Always | In 1 condition |
| RNU6ATACRNA, U6atac small nuclear | Always | In 1 condition |
| SEL1LSEL1L adaptor subunit of SYVN1 ubiquitin ligase | Always | In 1 condition |
| SLC39A7solute carrier family 39 member 7 | Always | In 1 condition |
| SPI1Spi-1 proto-oncogene | Always | In 2 conditions |
| TCF3transcription factor 3 | Always | In 3 conditions |
| BLNKB cell linker | Very often (80–99%) | In 2 conditions |
| CD79BCD79b molecule | Very often (80–99%) | In 2 conditions |
| IGHMimmunoglobulin heavy constant mu | Very often (80–99%) | In 2 conditions |
| IGLL1immunoglobulin lambda like polypeptide 1 | Very often (80–99%) | In 2 conditions |
| LRRC8Aleucine rich repeat containing 8 VRAC subunit A | Very often (80–99%) | In 2 conditions |
| PIK3CDphosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | Very often (80–99%) | In 1 condition |
| PIK3R1phosphoinositide-3-kinase regulatory subunit 1 | Very often (80–99%) | In 2 conditions |
| IKBKBinhibitor of nuclear factor kappa B kinase subunit beta | Often (30–79%) | In 1 condition |
| TIMM8Atranslocase of inner mitochondrial membrane 8A | Sometimes (5–29%) | In 1 condition |
| TTC7Atetratricopeptide repeat domain 7A | Sometimes (5–29%) | In 1 condition |
| CDCA7cell division cycle associated 7 | Not recorded | In 1 condition |
| CIITAclass II major histocompatibility complex transactivator | Not recorded | In 1 condition |
| HELLShelicase, lymphoid specific | Not recorded | In 1 condition |
| IL2RGinterleukin 2 receptor subunit gamma | Not recorded | In 1 condition |
How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.
Broader traits
Where this comes from
- The Human Phenotype Ontology, release 2026-09-01: the trait, its names, its definition and the genes linked to it. Find out more at hpo.jax.org.
- Data release 2026.10.16-c6eea6bf.
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