Traits

Traits linked to RAB28

RAB28, member RAS oncogene family

The Human Phenotype Ontology links 20 traits to RAB28, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the eye

Trait	How often it is seen
Cone/cone-rod dystrophy	Always
Decreased clarity of vision	Always
Severe near sightedness	Always
Abnormal retinal pigmentation	Very often (80–99%)
Difficulties with night vision	Very often (80–99%)
Extreme sensitivity of the eyes to light	Very often (80–99%)
Abnormal color vision	Often (30–79%)
Abnormal full-field electroretinogram	Often (30–79%)
Blind spot located at fixation point	Often (30–79%)
Color blindness	Often (30–79%)
Foveal hyperpigmentation	Often (30–79%)
Optic disc pallor	Often (30–79%)
Progressive loss of vision	Often (30–79%)
Retinal atrophy	Often (30–79%)
Spicular pigmentation of the retina	Often (30–79%)
Foveal atrophy	Sometimes (5–29%)
Involuntary, rapid, rhythmic eye movements	Sometimes (5–29%)
Metamorphopsia	Sometimes (5–29%)
Visual impairment	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Narrowing of blood vessels in back of eye	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to RAB28 and how often each is seen. Find out more at hpo.jax.org.

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