Skip to content
Use your HSA or FSA funds
Sequence your genome (opens in a new tab)

Gene

USP21

ubiquitin specific peptidase 21

Summary

Cytogenetic location
1q23.3
Coordinates
Chromosome 1: 161,159,500–161,165,723 (GRCh38)
Exons
14 exons across 6.2 kb
Protein
565 amino acids
Also known as
USP16
Previous symbols
USP23
MANE Select transcript
ENST00000368002.8NM_001014443.3
Locus type
Protein-coding
  • Very high
  • Confident
  • Low
  • Very low

Curated reports relevant to this gene

No Genome Test report reads USP21 yet. The test sequences your whole genome, so your data includes it all the same.

How USP21 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome 1, with a bracket where USP21 sits. USP21 and 36 genes near it on chromosome 1, from 160,662,612 to 161,662,611.Chromosome 11q23.3p36.33p36.32p36.31p36.23p36.22p36.21p36.13p36.12p36.11p35.3p35.2p35.1p34.3p34.2p34.1p33p32.3p32.2p32.1p31.3p31.2p31.1p22.3p22.2p22.1p21.3p21.2p21.1p13.3p13.2p13.1p12p11.2p11.1q11q12q21.1q21.2q21.3q22q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q31.1q31.2q31.3q32.1q32.2q32.3q41q42.11q42.12q42.13q42.2q42.3q43q44160.8 Mb161 Mb161.2 Mb161.4 Mb161.6 MbCD48: 160,678,746–160,711,831, reverse strandCD48SLAMF7: 160,739,057–160,754,821, forward strandSLAMF7LY9: 160,796,071–160,828,601, forward strandLY9CD244: 160,829,075–160,862,904, reverse strandCD244ITLN1: 160,876,539–160,893,012, reverse strandITLN1ITLN2: 160,944,266–160,954,889, reverse strandITLN2F11R: 160,985,714–161,023,123, reverse strand: 160,997,957–161,038,962, reverse strandTSTD1: 161,037,619–161,039,118, reverse strandTSTD1USF1: 161,039,249–161,045,982, reverse strandUSF1ARHGAP30: 161,046,944–161,069,970, reverse strandARHGAP30NECTIN4: 161,070,988–161,090,045, reverse strandKLHDC9: 161,098,343–161,100,346, forward strandKLHDC9PFDN2: 161,100,556–161,118,070, reverse strandPFDN2NIT1: 161,118,082–161,125,812, forward strandDEDD: 161,120,957–161,133,280, reverse strandDEDDUFC1: 161,152,776–161,159,368, forward strandUFC1USP21: 161,159,500–161,165,723, forward strandUSP21PPOX: 161,165,837–161,178,576, forward strandPPOXB4GALT3: 161,171,304–161,178,652, reverse strandB4GALT3ADAMTS4: 161,184,302–161,200,509, reverse strandNDUFS2: 161,197,104–161,214,723, forward strandFCER1G: 161,215,175–161,220,709, forward strandAPOA2: 161,222,290–161,227,266, reverse strandAPOA2TOMM40L: 161,225,939–161,233,755, forward strandNR1I3: 161,228,775–161,238,276, reverse strandPCP4L1: 161,258,136–161,285,450, forward strandPCP4L1MPZ: 161,304,735–161,309,974, reverse strandMPZSDHC: 161,314,352–161,363,774, forward strandSDHCCFAP126: 161,364,733–161,367,885, reverse strandCFAP126FCGR2A: 161,505,415–161,524,013, forward strandFCGR2AHSPA6: 161,524,540–161,526,894, forward strandHSPA6FCGR3A: 161,541,738–161,550,968, reverse strandFCGR3A: 161,544,807–161,631,456, reverse strandFCGR2C: 161,581,339–161,605,662, forward strandFCGR2CFCGR3B: 161,623,193–161,631,963, reverse strandFCGR3BFCGR2B: 161,661,958–161,679,490, forward strandFCGR2BDiagram of USP21: 14 exons on the forward strand of chromosome 1Exon 1: 161,159,500–161,159,678, 179 basesExon 2: 161,160,366–161,160,506, 141 basesExon 3: 161,160,620–161,161,240, 621 basesExon 4: 161,162,038–161,162,097, 60 basesExon 5: 161,162,270–161,162,390, 121 basesExon 6: 161,162,615–161,162,726, 112 basesExon 7: 161,162,919–161,163,074, 156 basesExon 8: 161,163,555–161,163,619, 65 basesExon 9: 161,163,878–161,163,981, 104 basesExon 10: 161,164,164–161,164,250, 87 basesExon 11: 161,164,534–161,164,612, 79 basesExon 12: 161,164,835–161,164,942, 108 basesExon 13: 161,165,029–161,165,143, 115 basesExon 14: 161,165,357–161,165,723, 367 bases12345678910111213145′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 6.2 kb; 1,698 of those bases code for the protein.

Sequencing USP21

1Easy

How hard USP21 is to sequence with short reads, out of 100

Almost all of USP21's exons sit where short reads map cleanly.

What adds to it: the share of USP21's exons in each kind of hard region

  • Mappability0%
  • Homology0%
  • Repeats3.4%
  • GC content7.7%
  • Reference coverage0%

A Dante Labs score from our own research, built on NIST's Genome in a Bottle maps of hard-to-sequence regions.How it's scored

1

position in USP21 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 6.2 kb of USP21, introns included, not only the 2.3 kb of exons.

ClinVar pathogenic variants (1)

The USP21 variants ClinVar classifies pathogenic or likely pathogenic for any condition, reviewed by at least one submitter with criteria, and the most reviewed of them. It is ClinVar's public record of the gene, never a result.

  • Pathogenic 1
VariantConditionsClinVar classificationReview status
NM_001122764.3(PPOX):c.420del (p.Glu141fs) (opens in a new tab)variegate porphyriaPathogenic1 star out of 4 criteria provided, single submitter

External links

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Genome in a Bottle genome stratifications, from NIST: the sequencing difficulty score.
  • Data release 2026.10.17-8666dff2.

Cite this page

APA

Dante Labs. (n.d.). USP21 gene: ubiquitin specific peptidase 21. Retrieved 18 October 2026, from https://dantelabs.com/genes/usp21

Vancouver

Dante Labs. USP21 gene: ubiquitin specific peptidase 21 [Internet]. [cited 18 October 2026]. Available from: https://dantelabs.com/genes/usp21

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test