Traits

Traits linked to KCNN2

potassium calcium-activated channel subfamily N member 2

The Human Phenotype Ontology links 38 traits to KCNN2, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Dystonia	Always
Hand tremor	Always
Intellectual disability	Always
Delayed speech and language development	Very often (80–99%)
Global developmental delay	Very often (80–99%)
Motor delay	Very often (80–99%)
Anxiety	Often (30–79%)
Ataxia	Often (30–79%)
Attention deficit	Often (30–79%)
Autism spectrum disorder	Often (30–79%)
Clumsy tandem walking	Often (30–79%)
Head tremor	Often (30–79%)
Intention tremor	Often (30–79%)
Jerking	Often (30–79%)
Motor tics	Often (30–79%)
Writer's cramp	Often (30–79%)
Abnormal periventricular white matter morphology	Sometimes (5–29%)
Chorea	Sometimes (5–29%)
Delayed CNS myelination	Sometimes (5–29%)
Dilated third ventricle	Sometimes (5–29%)
Disorder of involuntary muscle movements	Sometimes (5–29%)
Grand mal seizures	Sometimes (5–29%)
Nocturnal seizures	Sometimes (5–29%)
Panic attack	Sometimes (5–29%)
Parkinsonism	Sometimes (5–29%)
Psychosis	Sometimes (5–29%)
Repetitive movements	Sometimes (5–29%)
Resting tremor	Sometimes (5–29%)
Slow movements	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Impaired smooth pursuit	Often (30–79%)
Rotary nystagmus	Often (30–79%)
Drooping upper eyelid	Sometimes (5–29%)
Duane anomaly	Sometimes (5–29%)
Hypermetric saccades	Sometimes (5–29%)
Lazy eye	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Wry neck	Often (30–79%)
Abnormally small head	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Cogwheel rigidity	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to KCNN2 and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test