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Gene

DMC1

DNA meiotic recombinase 1

Summary

Cytogenetic location
22q13.1
Coordinates
Chromosome 22: 38,518,948–38,570,183 (GRCh38)
Exons
14 exons across 51.2 kb
Protein
340 amino acids
Also known as
LIM15
MANE Select transcript
ENST00000216024.7NM_007068.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Male Infertility

    • The inability of the male to effect fertilization of an ovum after a specified period of unprotected intercourse. Male sterility is permanent infertility.

      • 1 GenCC submitter rates it definitive or strong

How DMC1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 22, with a bracket where DMC1 sits. DMC1 and 26 genes near it on chromosome 22, from 38,044,566 to 39,044,565.Chromosome 2222q13.1p13p12p11.2p11.1q11.1q11.21q11.22q11.23q12.1q12.2q12.3q13.1q13.2q13.31q13.32q13.3338.2 Mb38.4 Mb38.6 Mb38.8 Mb39 MbPICK1: 38,056,311–38,076,050, forward strandPICK1SLC16A8: 38,078,134–38,084,186, reverse strandSLC16A8BAIAP2L2: 38,084,652–38,111,015, reverse strandBAIAP2L2PLA2G6: 38,111,495–38,214,778, reverse strandPLA2G6MAFF: 38,200,767–38,219,321, forward strandMAFFTMEM184B: 38,215,914–38,273,805, reverse strandTMEM184BCSNK1E: 38,281,747–38,320,044, reverse strandCSNK1ETPTEP2-CSNK1E: 38,291,918–38,398,522, reverse strandTPTEP2-CSNK1EKCNJ4: 38,426,327–38,455,902, reverse strandKCNJ4KDELR3: 38,468,021–38,483,762, forward strandKDELR3DDX17: 38,483,438–38,507,660, reverse strandDDX17DMC1: 38,518,948–38,570,183, reverse strandDMC1FAM227A: 38,578,118–38,656,629, reverse strandFAM227ACBY1: 38,656,375–38,673,920, forward strandCBY1TOMM22: 38,681,924–38,687,684, forward strandTOMM22JOSD1: 38,685,543–38,701,556, reverse strandJOSD1GTPBP1: 38,705,742–38,738,299, forward strandGTPBP1SUN2: 38,733,280–38,794,198, reverse strandSUN2DNAL4: 38,778,505–38,794,198, reverse strandDNAL4NPTXR: 38,818,452–38,844,036, reverse strandNPTXRCBX6: 38,861,422–38,872,249, reverse strandCBX6APOBEC3A: 38,952,741–38,963,184, forward strandAPOBEC3AAPOBEC3B: 38,982,347–38,992,804, forward strandAPOBEC3BAPOBEC3C: 39,014,163–39,020,352, forward strandAPOBEC3C: 39,014,363–39,033,276, forward strandAPOBEC3D: 39,020,952–39,034,327, forward strandAPOBEC3DAPOBEC3F: 39,040,604–39,055,972, forward strandDiagram of DMC1: 14 exons on the reverse strand of chromosome 22Exon 14: 38,518,948–38,520,089, 1,142 basesExon 13: 38,521,608–38,521,724, 117 basesExon 12: 38,537,592–38,537,652, 61 basesExon 11: 38,538,295–38,538,409, 115 basesExon 10: 38,538,539–38,538,612, 74 basesExon 9: 38,539,321–38,539,412, 92 basesExon 8: 38,549,925–38,549,997, 73 basesExon 7: 38,552,666–38,552,707, 42 basesExon 6: 38,555,357–38,555,409, 53 basesExon 5: 38,562,287–38,562,369, 83 basesExon 4: 38,566,590–38,566,736, 147 basesExon 3: 38,567,583–38,567,627, 45 basesExon 2: 38,568,206–38,568,289, 84 basesExon 1: 38,570,043–38,570,183, 141 bases1410515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.3 kb of the gene's 51.2 kb; 1,023 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). DMC1 gene: DNA meiotic recombinase 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/dmc1

Vancouver

Dante Labs. DMC1 gene: DNA meiotic recombinase 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/dmc1

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