Traits

Traits linked to COPA

coat protein complex I subunit alpha

The Human Phenotype Ontology links 15 traits to COPA, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the respiratory system

Trait	How often it is seen
Abnormality in area between air sacs in lung	Always
Hemosiderin-laden macrophages in bronchoalveolar fluid	Always
Stiff lung or chest wall causing decreased lung volume	Always
Breathing difficulty	Sometimes (5–29%)
Cough	Sometimes (5–29%)
Increased respiratory rate or depth of breathing	Sometimes (5–29%)
Decreased DLCO	Not recorded

Abnormality of the genitourinary system

Trait	How often it is seen
Crescentic glomerulonephritis	Often (30–79%)
Mesangial hypercellularity	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Elevated circulating C-reactive protein concentration	Not recorded
High ESR	Not recorded

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Pulmonary hemorrhage	Often (30–79%)

Abnormality of the immune system

Trait	How often it is seen
Antinuclear antibody positivity	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthritis	Very often (80–99%)

Constitutional symptom

Trait	How often it is seen
Joint pain	Sometimes (5–29%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to COPA and how often each is seen. Find out more at hpo.jax.org.

One test. A lifetime of answers.

From $449Free shipping · Results in 6–8 weeks

Get my Genome Test