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Gene

CFP

complement factor properdin

Summary

Cytogenetic location
Xp11.23
Coordinates
Chromosome X: 47,623,282–47,629,930 (GRCh38)
Exons
9 exons across 6.6 kb
Protein
469 amino acids
Inheritance
X-linked recessive
Previous symbols
PFC
MANE Select transcript
ENST00000396992.8NM_001145252.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

  • Inherited Complement and Properdin Deficiencies

    • Properdin deficiency, X-linkedX-linked recessive

      Caused by changes in CFP, it affects mainly males and predisposes to severe meningococcal disease.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Meningococcal vaccination of affected males reduces the risk of severe infection.

Broader groupings

  • Other Inborn Errors of Immunity

    • Inborn error of immunity

      One of 114 genes linked to it

      Inherited disorders of the immune system caused by changes in single genes, affecting how the body fights infection or regulates inflammation.

      • 1 GenCC submitter rates it definitive or strong

Inheritance

X-linked recessive
The change is on the X chromosome, so one copy affects males, who have one X, while females with one are usually carriers. A carrier mother passes it on to each child with a one-in-two chance.

How CFP is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
Chromosome X, with a bracket where CFP sits. CFP and 16 genes near it on chromosome X, from 47,126,606 to 48,126,605.Chromosome XXp11.23p22.33p22.32p22.31p22.2p22.13p22.12p22.11p21.3p21.2p21.1p11.4p11.3p11.23p11.22p11.21p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.31q21.32q21.33q22.1q22.2q22.3q23q24q25q26.1q26.2q26.3q27.1q27.2q27.3q2847.2 Mb47.4 Mb47.6 Mb47.8 Mb48 MbNDUFB11: 47,142,071–47,145,507, reverse strandNDUFB11RBM10: 47,144,284–47,186,814, forward strandRBM10UBA1: 47,190,713–47,215,173, forward strandUBA1CDK16: 47,217,860–47,230,000, forward strandCDK16USP11: 47,232,866–47,248,328, forward strandUSP11ZNF157: 47,366,479–47,414,624, forward strandZNF157ZNF41: 47,444,693–47,483,247, reverse strandZNF41ARAF: 47,561,043–47,571,921, forward strandARAFSYN1: 47,571,890–47,619,970, reverse strandSYN1TIMP1: 47,582,227–47,586,793, forward strandTIMP1CFP: 47,623,282–47,629,930, reverse strandCFPELK1: 47,631,617–47,650,604, reverse strandELK1UXT: 47,651,792–47,659,301, reverse strandUXTZNF81: 47,836,471–48,003,066, forward strandZNF81ZNF182: 47,974,851–48,004,375, reverse strandZNF182ZNF630: 47,983,356–48,071,893, reverse strandZNF630SPACA5: 48,004,336–48,009,735, forward strandSPACA5Diagram of CFP: 9 exons on the reverse strand of chromosome XExon 9: 47,623,282–47,624,440, 1,159 basesExon 8: 47,626,058–47,626,169, 112 basesExon 7: 47,626,328–47,626,519, 192 basesExon 6: 47,626,773–47,626,946, 174 basesExon 5: 47,627,141–47,627,332, 192 basesExon 4: 47,627,471–47,627,641, 171 basesExon 3: 47,628,102–47,628,277, 176 basesExon 2: 47,629,524–47,629,674, 151 basesExon 1: 47,629,769–47,629,930, 162 bases9876543215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 2.5 kb of the gene's 6.6 kb; 1,410 of those bases code for the protein.

How a genome test reads CFP

1

position in CFP where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 6.6 kb of CFP, introns included, not only the 2.5 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). CFP gene: complement factor properdin. Retrieved 16 October 2026, from https://dantelabs.com/genes/cfp

Vancouver

Dante Labs. CFP gene: complement factor properdin [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/cfp

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