Traits

Traits linked to CD4

CD4 molecule

The Human Phenotype Ontology links 54 traits to CD4, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of the nervous system

Trait	How often it is seen
Depression	Very often (80–99%)
Jerking	Very often (80–99%)
Loss of developmental milestones	Very often (80–99%)
Difficulty sleeping	Often (30–79%)
Abnormal pyramidal sign	Sometimes (5–29%)
Ataxia	Sometimes (5–29%)
Cranial nerve paralysis	Sometimes (5–29%)
Epilepsy	Sometimes (5–29%)
Extreme thirst	Sometimes (5–29%)
Peripheral neuropathy	Sometimes (5–29%)
Rise in pressure inside skull	Sometimes (5–29%)
Too much cerebrospinal fluid in the brain	Sometimes (5–29%)

Abnormality of the cardiovascular system

Trait	How often it is seen
Swollen lymph nodes in center of chest	Very often (80–99%)
Increased spleen size	Often (30–79%)
Low blood pressure	Often (30–79%)
Heart attack	Sometimes (5–29%)
Inflammation of heart muscle	Sometimes (5–29%)
Swelling or irritation of membrane around heart	Sometimes (5–29%)

Abnormality of the digestive system

Trait	How often it is seen
Abdominal pain	Very often (80–99%)
Anorexia	Very often (80–99%)
Diarrhea	Very often (80–99%)
Malabsorption	Very often (80–99%)
Enlarged liver	Often (30–79%)

Abnormality of blood and blood-forming tissues

Trait	How often it is seen
Decreased total CD4+ T cell proportion	Always
Gastrointestinal bleeding	Sometimes (5–29%)
Low number of red blood cells or hemoglobin	Sometimes (5–29%)
Abnormal T cell morphology	Not recorded

Constitutional symptom

Trait	How often it is seen
Fatigue	Very often (80–99%)
Joint pain	Very often (80–99%)
Muscle ache	Often (30–79%)
Chest pain	Sometimes (5–29%)

Abnormality of limbs

Trait	How often it is seen
Palmar warts	Always
Plantar warts	Always
Fluid accumulation in lower limbs	Sometimes (5–29%)

Abnormality of the respiratory system

Trait	How often it is seen
Inflammation of tissues lining lungs and chest	Often (30–79%)
Cough	Sometimes (5–29%)
Respiratory function loss	Sometimes (5–29%)

Laboratory abnormality

Trait	How often it is seen
Fever	Very often (80–99%)
Body fails to respond to insulin	Sometimes (5–29%)
Low blood sodium levels	Sometimes (5–29%)

Abnormality of the eye

Trait	How often it is seen
Uveitis	Often (30–79%)
Bulging eye	Sometimes (5–29%)

Abnormality of the immune system

Trait	How often it is seen
Brain inflammation	Sometimes (5–29%)
Muscle inflammation	Sometimes (5–29%)

Abnormality of the integument

Trait	How often it is seen
Disseminated cutaneous warts	Always
Generalized hyperpigmentation	Sometimes (5–29%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Arthritis	Very often (80–99%)
Muscle weakness	Sometimes (5–29%)

Abnormality of head or neck

Trait	How often it is seen
Recurrent colds	Always

Abnormality of the breast

Trait	How often it is seen
Spontaneous milk flow from breast	Sometimes (5–29%)

Abnormality of the ear

Trait	How often it is seen
Recurrent middle ear infection	Always

Abnormality of the endocrine system

Trait	How often it is seen
Underactive thyroid	Sometimes (5–29%)

Abnormality of the genitourinary system

Trait	How often it is seen
Abnormal erection	Sometimes (5–29%)

Growth abnormality

Trait	How often it is seen
Wasting syndrome	Very often (80–99%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to CD4 and how often each is seen. Find out more at hpo.jax.org.

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