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Gene

ACP4

acid phosphatase 4

Summary

Cytogenetic location
19q13.33
Coordinates
Chromosome 19: 50,790,415–50,795,219 (GRCh38)
Exons
11 exons across 4.8 kb
Protein
426 amino acids
Inheritance
Autosomal dominant
Previous symbols
ACPT
MANE Select transcript
ENST00000270593.2NM_033068.3
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How ACP4 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
Chromosome 19, with a bracket where ACP4 sits. ACP4 and 40 genes near it on chromosome 19, from 50,292,817 to 51,292,816.Chromosome 1919q13.33p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4350.4 Mb50.6 Mb50.8 Mb51 Mb51.2 MbMYH14: 50,188,181–50,310,545, forward strandMYH14KCNC3: 50,311,937–50,333,515, reverse strandKCNC3NR1H2: 50,329,639–50,383,404, forward strandNR1H2NAPSA: 50,358,472–50,369,342, reverse strandNAPSAPOLD1: 50,384,204–50,418,018, forward strandPOLD1: 50,415,799–50,428,409, forward strandSPIB: 50,418,931–50,431,314, forward strandSPIBMYBPC2: 50,432,772–50,466,328, forward strandMYBPC2GARIN5A: 50,466,785–50,476,866, reverse strandGARIN5AEMC10: 50,476,400–50,510,789, forward strandEMC10JOSD2: 50,505,995–50,511,376, reverse strandJOSD2ASPDH: 50,511,568–50,514,696, reverse strandASPDHLRRC4B: 50,516,892–50,568,435, reverse strandLRRC4BSYT3: 50,621,307–50,640,040, reverse strandSYT3C19orf81: 50,648,792–50,659,310, forward strandC19orf81SHANK1: 50,659,255–50,719,802, reverse strandSHANK1CLEC11A: 50,723,283–50,725,719, forward strandCLEC11AGPR32: 50,770,464–50,771,732, forward strandGPR32SMIM47: 50,776,141–50,793,142, reverse strandSMIM47ACP4: 50,790,415–50,795,219, forward strandACP4KLK1: 50,819,146–50,823,787, reverse strandKLK1KLK15: 50,825,289–50,837,213, reverse strandKLK15KLK3: 50,854,915–50,860,767, forward strandKLK3KLK2: 50,861,568–50,880,567, forward strandKLK2KLK4: 50,906,351–50,911,395, reverse strandKLK4KLK5: 50,943,249–50,953,314, reverse strandKLK5KLK6: 50,958,631–50,969,673, reverse strandKLK6KLK7: 50,976,468–50,984,099, reverse strandKLK7KLK8: 50,996,007–51,002,711, reverse strandKLK8: 50,996,018–51,009,581, reverse strandKLK9: 51,002,508–51,009,634, reverse strandKLK9KLK10: 51,012,739–51,021,048, reverse strandKLK11: 51,022,216–51,028,060, reverse strandKLK12: 51,029,092–51,035,230, reverse strandKLK12KLK13: 51,055,625–51,065,801, reverse strandKLK13KLK14: 51,077,317–51,086,530, reverse strandKLK14CTU1: 51,095,343–51,108,426, reverse strandCTU1SIGLEC9: 51,124,871–51,141,053, forward strandSIGLEC9SIGLEC7: 51,142,288–51,153,702, forward strandSIGLEC7CD33: 51,217,033–51,243,860, forward strandCD33SIGLECL1: 51,246,348–51,269,330, forward strandSIGLECL1Diagram of ACP4: 11 exons on the forward strand of chromosome 19Exon 3: 1 known disease-causing siteExon 4: 2 known disease-causing sitesExon 7: 3 known disease-causing sitesExon 8: 1 known disease-causing siteExon 9: 1 known disease-causing siteExon 1: 50,790,415–50,790,525, 111 basesExon 2: 50,790,594–50,790,698, 105 basesExon 3: 50,790,774–50,790,860, 87 basesExon 4: 50,791,656–50,791,802, 147 basesExon 5: 50,792,073–50,792,171, 99 basesExon 6: 50,792,242–50,792,337, 96 basesExon 7: 50,793,684–50,793,816, 133 basesExon 8: 50,793,888–50,793,970, 83 basesExon 9: 50,794,457–50,794,581, 125 basesExon 10: 50,794,786–50,794,964, 179 basesExon 11: 50,795,043–50,795,219, 177 bases12345678910115′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.3 kb of the gene's 4.8 kb; 1,281 of those bases code for the protein.

How a genome test reads ACP4

9

positions in ACP4 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 4.8 kb of ACP4, introns included, not only the 1.3 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). ACP4 gene: acid phosphatase 4. Retrieved 17 October 2026, from https://dantelabs.com/genes/acp4

Vancouver

Dante Labs. ACP4 gene: acid phosphatase 4 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/acp4

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