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Gene

SHANK1

SH3 and multiple ankyrin repeat domains 1

Summary

Cytogenetic location
19q13.33
Coordinates
Chromosome 19: 50,659,255–50,719,802 (GRCh38)
Exons
24 exons across 60.5 kb
Protein
2,161 amino acids
Also known as
SSTRIP, SPANK-1, synamon
MANE Select transcript
ENST00000293441.6NM_016148.5
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

  • Autism Spectrum Disorder

    • A spectrum of developmental disorders that includes autism, and Asperger syndrome. Signs and symptoms include poor communication skills, defective social interactions, and repetitive behaviors.

      • 1 GenCC submitter rates it definitive or strong
      What knowing changes

      Early intervention services, behavioral therapy, speech and occupational therapy, psychopharmacology for associated features

How SHANK1 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 19, with a bracket where SHANK1 sits. SHANK1 and 38 genes near it on chromosome 19, from 50,189,529 to 51,189,528.Chromosome 1919q13.33p13.3p13.2p13.13p13.12p13.11p12p11q11q12q13.11q13.12q13.13q13.2q13.31q13.32q13.33q13.41q13.42q13.4350.2 Mb50.4 Mb50.6 Mb50.8 Mb51 MbMYH14: 50,188,181–50,310,545, forward strandMYH14KCNC3: 50,311,937–50,333,515, reverse strandKCNC3NR1H2: 50,329,639–50,383,404, forward strandNR1H2NAPSA: 50,358,472–50,369,342, reverse strandNAPSAPOLD1: 50,384,204–50,418,018, forward strandPOLD1: 50,415,799–50,428,409, forward strandSPIB: 50,418,931–50,431,314, forward strandSPIBMYBPC2: 50,432,772–50,466,328, forward strandMYBPC2GARIN5A: 50,466,785–50,476,866, reverse strandGARIN5AEMC10: 50,476,400–50,510,789, forward strandEMC10JOSD2: 50,505,995–50,511,376, reverse strandJOSD2ASPDH: 50,511,568–50,514,696, reverse strandASPDHLRRC4B: 50,516,892–50,568,435, reverse strandLRRC4BSYT3: 50,621,307–50,640,040, reverse strandSYT3C19orf81: 50,648,792–50,659,310, forward strandC19orf81SHANK1: 50,659,255–50,719,802, reverse strandSHANK1CLEC11A: 50,723,283–50,725,719, forward strandCLEC11AGPR32: 50,770,464–50,771,732, forward strandGPR32SMIM47: 50,776,141–50,793,142, reverse strandSMIM47ACP4: 50,790,415–50,795,219, forward strandACP4KLK1: 50,819,146–50,823,787, reverse strandKLK1KLK15: 50,825,289–50,837,213, reverse strandKLK15KLK3: 50,854,915–50,860,767, forward strandKLK3KLK2: 50,861,568–50,880,567, forward strandKLK2KLK4: 50,906,351–50,911,395, reverse strandKLK4KLK5: 50,943,249–50,953,314, reverse strandKLK5KLK6: 50,958,631–50,969,673, reverse strandKLK6KLK7: 50,976,468–50,984,099, reverse strandKLK7KLK8: 50,996,007–51,002,711, reverse strandKLK8: 50,996,018–51,009,581, reverse strandKLK9: 51,002,508–51,009,634, reverse strandKLK9KLK10: 51,012,739–51,021,048, reverse strandKLK11: 51,022,216–51,028,060, reverse strandKLK12: 51,029,092–51,035,230, reverse strandKLK12KLK13: 51,055,625–51,065,801, reverse strandKLK13KLK14: 51,077,317–51,086,530, reverse strandKLK14CTU1: 51,095,343–51,108,426, reverse strandCTU1SIGLEC9: 51,124,871–51,141,053, forward strandSIGLEC9SIGLEC7: 51,142,288–51,153,702, forward strandSIGLEC7Diagram of SHANK1: 24 exons on the reverse strand of chromosome 19Exon 24: 50,659,255–50,662,682, 3,428 basesExon 23: 50,666,192–50,669,285, 3,094 basesExon 22: 50,672,018–50,672,114, 97 basesExon 21: 50,686,237–50,686,355, 119 basesExon 20: 50,686,744–50,686,812, 69 basesExon 19: 50,687,582–50,687,662, 81 basesExon 18: 50,687,923–50,688,058, 136 basesExon 17: 50,688,844–50,688,968, 125 basesExon 16: 50,689,197–50,689,279, 83 basesExon 15: 50,697,096–50,697,122, 27 basesExon 14: 50,697,589–50,697,664, 76 basesExon 13: 50,697,843–50,697,956, 114 basesExon 12: 50,702,467–50,702,660, 194 basesExon 11: 50,703,500–50,703,830, 331 basesExon 10: 50,704,120–50,704,186, 67 basesExon 9: 50,704,437–50,704,514, 78 basesExon 8: 50,711,371–50,711,487, 117 basesExon 7: 50,711,947–50,712,114, 168 basesExon 6: 50,713,798–50,713,949, 152 basesExon 5: 50,714,182–50,714,290, 109 basesExon 4: 50,715,659–50,715,730, 72 basesExon 3: 50,716,275–50,716,478, 204 basesExon 2: 50,716,665–50,716,962, 298 basesExon 1: 50,719,406–50,719,802, 397 bases24201510515′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 9.6 kb of the gene's 60.5 kb; 6,486 of those bases code for the protein.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). SHANK1 gene: SH3 and multiple ankyrin repeat domains 1. Retrieved 17 October 2026, from https://dantelabs.com/genes/shank1

Vancouver

Dante Labs. SHANK1 gene: SH3 and multiple ankyrin repeat domains 1 [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/shank1

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