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Gene

GPR68

G protein-coupled receptor 68

Summary

Cytogenetic location
14q32.11
Coordinates
Chromosome 14: 91,232,532–91,244,704 (GRCh38)
Exons
2 exons across 12.2 kb
Protein
365 amino acids
Inheritance
Autosomal dominant
Also known as
OGR1
MANE Select transcript
ENST00000650645.1NM_001177676.2
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated report relevant to this gene

Inheritance

Autosomal dominant
One changed copy, from either parent, is enough. A parent who has one passes it on to each child with a one-in-two chance.

How GPR68 is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Known disease-causing sites
  • Stretches short reads find hard
Chromosome 14, with a bracket where GPR68 sits. GPR68 and 6 genes near it on chromosome 14, from 90,738,618 to 91,738,617.Chromosome 1414q32.11p13p12p11.2p11.1q11.1q11.2q12q13.1q13.2q13.3q21.1q21.2q21.3q22.1q22.2q22.3q23.1q23.2q23.3q24.1q24.2q24.3q31.1q31.2q31.3q32.11q32.12q32.13q32.2q32.31q32.32q32.3390.8 Mb91 Mb91.2 Mb91.4 Mb91.6 MbTTC7B: 90,524,564–90,816,525, reverse strandTTC7BRPS6KA5: 90,847,861–91,060,685, reverse strandRPS6KA5DGLUCY: 91,060,044–91,226,930, forward strandDGLUCYGPR68: 91,232,532–91,244,704, reverse strandGPR68CCDC88C: 91,271,323–91,417,890, reverse strandCCDC88CPPP4R3A: 91,457,139–91,510,556, reverse strandPPP4R3ACATSPERB: 91,580,696–91,780,707, reverse strandCATSPERBDiagram of GPR68: 2 exons on the reverse strand of chromosome 14Exon 2: 1 known disease-causing siteExon 2: 91,232,532–91,235,179, 2,648 basesExon 1: 91,244,297–91,244,704, 408 bases215′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 3.1 kb of the gene's 12.2 kb; 1,098 of those bases code for the protein.

How a genome test reads GPR68

1

position in GPR68 where ClinVar classes a change as pathogenic or likely pathogenic

None of them falls in a region short reads find hard.

A whole genome covers all 12.2 kb of GPR68, introns included, not only the 3.1 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • GenCC and ClinGen, released 2026-10-16: which conditions the gene is linked to, and how strongly.
  • The ACMG secondary findings list, SF v3.2.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • The Human Phenotype Ontology, release 2026-09-01: the traits linked to the gene. Find out more at hpo.jax.org.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). GPR68 gene: G protein-coupled receptor 68. Retrieved 16 October 2026, from https://dantelabs.com/genes/gpr68

Vancouver

Dante Labs. GPR68 gene: G protein-coupled receptor 68 [Internet]. [cited 16 October 2026]. Available from: https://dantelabs.com/genes/gpr68

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