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Gene

BPHL

biphenyl hydrolase like

Summary

Cytogenetic location
6p25.2
Coordinates
Chromosome 6: 3,118,711–3,153,578 (GRCh38)
Exons
7 exons across 34.9 kb
Protein
291 amino acids
Also known as
Bph-rp, VACVase
Previous symbols
MCNAA
MANE Select transcript
ENST00000380379.10NM_004332.4
Locus type
gene with protein product
  • Very high
  • Confident
  • Low
  • Very low

Reference genomeGRCh38

Positions on gene and variant pages follow this choice, in this browser.

Curated reports relevant to this gene

No Genome Test report reads BPHL yet. The test sequences your whole genome, so your data includes it all the same.

How BPHL is laid out

  • Coding sequence
  • Untranslated region
  • Intron
  • Direction of transcription
  • Stretches short reads find hard
Chromosome 6, with a bracket where BPHL sits. BPHL and 11 genes near it on chromosome 6, from 2,636,145 to 3,636,144.Chromosome 66p25.2p25.3p25.2p25.1p24.3p24.2p24.1p23p22.3p22.2p22.1p21.33p21.32p21.31p21.2p21.1p12.3p12.2p12.1p11.2p11.1q11.1q11.2q12q13q14.1q14.2q14.3q15q16.1q16.2q16.3q21q22.1q22.2q22.31q22.32q22.33q23.1q23.2q23.3q24.1q24.2q24.3q25.1q25.2q25.3q26q272.8 Mb3 Mb3.2 Mb3.4 Mb3.6 MbMYLK4: 2,663,629–2,770,381, reverse strandMYLK4WRNIP1: 2,765,323–2,791,517, forward strandWRNIP1SERPINB1: 2,832,332–2,842,035, reverse strandSERPINB1SERPINB9: 2,887,169–2,903,318, reverse strandSERPINB9SERPINB6: 2,944,468–2,972,375, reverse strandSERPINB6NQO2: 2,987,987–3,022,745, forward strandNQO2RIPK1: 3,063,824–3,115,188, forward strandRIPK1BPHL: 3,118,711–3,153,578, forward strandBPHLTUBB2A: 3,153,497–3,157,553, reverse strandTUBB2ATUBB2B: 3,223,324–3,231,730, reverse strandTUBB2BPSMG4: 3,231,403–3,304,360, forward strandPSMG4SLC22A23: 3,268,962–3,457,100, reverse strandSLC22A23Diagram of BPHL: 7 exons on the forward strand of chromosome 6Exon 1: 3,118,711–3,118,847, 137 basesExon 2: 3,123,657–3,123,760, 104 basesExon 3: 3,127,242–3,127,408, 167 basesExon 4: 3,129,045–3,129,198, 154 basesExon 5: 3,137,362–3,137,493, 132 basesExon 6: 3,140,386–3,140,509, 124 basesExon 7: 3,152,488–3,153,578, 1,091 bases12345675′3′

Exons of the gene's MANE Select transcript (release v1.5), from NCBI and EMBL-EBI, on the GRCh38 reference genome.

Chromosome bands from UCSC's GRCh38 ideogram (2022-10-29).

Nearby genes from Ensembl release 116, on GRCh38.

Exons make up 1.9 kb of the gene's 34.9 kb; 876 of those bases code for the protein.

How a genome test reads BPHL

1

position in BPHL where ClinVar classes a change as pathogenic or likely pathogenic

1 of them (100%) falls in a region short reads find hard.

  • Low mappability (1 site)Regions where 100 bp or 250 bp reads cannot be placed uniquely.
  • Segmental duplications (1 site)Copies of at least 1 kb sharing at least 90% identity with another part of the genome (paralogues, pseudogenes); reads may align to the wrong copy.

A whole genome covers all 34.9 kb of BPHL, introns included, not only the 1.9 kb of exons.

Where this comes from

  • HGNC: the gene's symbol, name, other symbols and location.
  • MANE Select v1.5, from NCBI and EMBL-EBI: the transcript, its exons and coding sequence.
  • ClinVar and the GIAB stratifications: known disease-causing sites, and the regions short reads find hard.
  • Data release 2026.10.16-c6eea6bf.

Cite this page

APA

Dante Labs. (n.d.). BPHL gene: biphenyl hydrolase like. Retrieved 17 October 2026, from https://dantelabs.com/genes/bphl

Vancouver

Dante Labs. BPHL gene: biphenyl hydrolase like [Internet]. [cited 17 October 2026]. Available from: https://dantelabs.com/genes/bphl

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