Traits

Traits linked to TRAIP

TRAF interacting protein

The Human Phenotype Ontology links 48 traits to TRAIP, by body system: features seen in people with one of the gene's rare conditions.

Abnormality of head or neck

Trait	How often it is seen
Abnormally small head	Always
Little lower jaw	Always
Long face	Always
Narrow face	Always
Beaked nose	Very often (80–99%)
Deformity of the skull	Very often (80–99%)
Abnormal tooth enamel	Often (30–79%)
Decreased number of teeth	Often (30–79%)
Downward slanting of the opening between the eyelids	Often (30–79%)
Long, narrow head	Often (30–79%)
Scaphocephaly	Often (30–79%)
Sparse scalp hair	Often (30–79%)

Abnormality of the musculoskeletal system

Trait	How often it is seen
Delayed bone maturation	Very often (80–99%)
Abnormal formation of the hip	Often (30–79%)
Cone-shaped end part of bone	Often (30–79%)
Double-Jointed	Often (30–79%)
Scoliosis	Sometimes (5–29%)
Congenital diaphragmatic hernia	Not recorded

Abnormality of the nervous system

Trait	How often it is seen
Global developmental delay	Always
Cognitive impairment	Very often (80–99%)
Intellectual disability	Very often (80–99%)
Mild global developmental delay	Very often (80–99%)
Simplified gyral pattern	Often (30–79%)
Ventriculomegaly	Often (30–79%)

Abnormality of the genitourinary system

Trait	How often it is seen
Agonadism	Not recorded
Ambiguous external genitalia	Not recorded
Enlarged clitoris	Not recorded
Frequent urinary tract infections	Not recorded

Growth abnormality

Trait	How often it is seen
Prenatal growth deficiency	Always
Short stature	Always
Wasting syndrome	Very often (80–99%)
Small for gestational age	Not recorded

Abnormality of limbs

Trait	How often it is seen
Curvature of little finger	Very often (80–99%)
Gap between 1st and 2nd toes	Very often (80–99%)
Club feet	Not recorded

Abnormality of the cardiovascular system

Trait	How often it is seen
Underdeveloped lung artery	Sometimes (5–29%)
An opening in the wall separating the top two chambers of the heart	Not recorded
Hole in heart wall separating two lower heart chambers	Not recorded

Abnormality of the ear

Trait	How often it is seen
Prominent ear	Always
Abnormal earlobe	Often (30–79%)
Absent earlobe	Often (30–79%)

Abnormality of prenatal development or birth

Trait	How often it is seen
High levels of amniotic fluid	Not recorded
Less than 10 fetal movements in 12 hours	Not recorded

Abnormality of the immune system

Trait	How often it is seen
Asthma	Often (30–79%)
Recurrent respiratory infections	Often (30–79%)

Abnormality of the integument

Trait	How often it is seen
Prematurely aged appearance	Very often (80–99%)
Excessive hair growth	Often (30–79%)

Abnormality of the eye

Trait	How often it is seen
Glaucoma	Often (30–79%)

How often is among people with one of the gene's conditions, the most often across them, as the Human Phenotype Ontology records it. These pages describe traits and the research behind them; they are not a diagnosis, and a doctor or genetic counsellor is the person to ask about symptoms.

Where this comes from

The Human Phenotype Ontology, release 2026-09-01: the traits linked to TRAIP and how often each is seen. Find out more at hpo.jax.org.

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